文献类型：期刊文献

英文题名：Effects of salt substitutes on blood pressure: a meta-analysis of randomized controlled trials

作者：Peng, Ya-Guang[1,2];Li, Wei[1,2];Wen, Xiao-Xiao[1,2];Li, Ying[1,2];Hu, Ji-Hong[3];Zhao, Lian-Cheng[1,2]

第一作者：Peng, Ya-Guang

通信作者：Zhao, LC[1]

机构：[1]Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China;[2]Peking Union Med Coll, Beijing 100037, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Sch Publ Hlth, Dunhuang, Gansu, Peoples R China

第一机构：Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China

通信机构：[1]corresponding author), Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China.

年份：2014

卷号：100

期号：6

起止页码：1448

外文期刊名：AMERICAN JOURNAL OF CLINICAL NUTRITION

收录：;Scopus(收录号：2-s2.0-84911426399);WOS:【SCI-EXPANDED(收录号:WOS:000345267600007)】；

基金：Supported by the China Capital Medical Science Development Fund (grant no. 2003-2013).

语种：英文

外文关键词：blood pressure; hypertension; meta-analysis; salt substitutes; randomized controlled trial

摘要：Background: Clinical trials assessing the effects of salt substitutes on blood pressure (BP) have reported mixed results. Objectives: A meta-analysis of randomized controlled trials was conducted to evaluate the effect of salt substitutes on BP, including systolic BP (SBP) and diastolic BP (DBP). Design: Studies were identified via systematic searches of the PubMed, Embase, Cochrane Library, Wanfang Data, and the China National Knowledge Infrastructure databases through December 2013. Random-effects models were used to estimate pooled mean differences in SBP and DBP. Results: Six cohorts from 5 articles (1 trial enrolled 2 cohorts for independent intervention) consisting of 1974 participants were included. Pooled results showed that salt substitutes had a significant effect on SBP (mean difference: -4.9 mm Hg; 95% CI: -7.3, -2.5 mm Hg; P < 0.001) and DBP (mean difference: -1.5 mm Hg; 95% CI: -2.7, -0.3 mm Hg; P = 0.013). Significant heterogeneity was found for both SBP (I-2 = 76.7%) and DBP (I-2 = 65.8%). The sensitivity analysis indicated that the pooled effects of salt substitutes on SBP and DBP were robust to systematically dropping each trial. Furthermore, no evidence of significant publication bias from funnel plots or Egger's tests (P = 0.17 and 0.22 for SBP and DBP, respectively) was found. Conclusion: This meta-analysis showed that salt-substitution strategies are effective at lowering SBP and DBP, which supports a nutritional approach to preventing hypertension.