文献类型：期刊文献

英文题名：Chinese medicines as therapeutic options for treating prostate cancer: Therapeutic effects and underlying mechanisms

作者：Li, Shenglong[1];Jing, Shuaishuai[1];Zhou, Jiuyun[2];Li, Hui[1];Yin, Pengdong[1];Zhang, Qingwei[3];Gong, Meisheng[4];Zhao, Yongqiang[2];Lu, Ganggang[1];Jin, Guangwei[1];Li, Xixiang[5];Liang, Yonglin[6];Su, Lining[1]

第一作者：李淑玲

通信作者：Zhao, YQ[1]

机构：[1]Gansu Univ Chinese Med, Coll Integrated Tradit & Western Med, Lanzhou, Peoples R China;[2]Gansu Prov Hosp Tradit Chinese Med, Urol Dept, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, First Clin Med Coll, Lanzhou, Peoples R China;[4]Heilongjiang Prov Acad Tradit Chinese Med, Grad Sch, Harbin, Peoples R China;[5]Gansu Prov Hosp Tradit Chinese Med, Pharm Dept, Lanzhou, Peoples R China;[6]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Urol Dept, Lanzhou, Peoples R China.

年份：2026

卷号：354

外文期刊名：JOURNAL OF ETHNOPHARMACOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001565292500009)】；

基金：The project is funded by the Regional Science Fund of the National Natural Science Foundation of China (No. 82460897) , the Project of Central Guided Local Science and Technology Development Funds (No. 24ZYQA037) , and the Project funded by Key Research and Development Funds of the Gansu Science and Technology Department (No. 22YF7FA101) , the Gansu Provincial Natural Science Foundation (No. 22JR5RA638) , Joint Research Fund Project of Gansu Province (No. 25JRRA1227) .

语种：英文

外文关键词：Prostate cancer; Traditional Chinese medicine; Pathogenesis; Therapeutic effects; Underlying mechanisms

摘要：Ethnopharmacological relevance: Prostate Cancer (PCa) remains a leading malignancy in males, with significant morbidity and mortality. Despite advancements in treatment, challenges like resistance, recurrence, and metastasis persist. Traditional Chinese Medicine (TCM) offers a promising adjunctive approach, enhancing treatment efficacy, reducing toxicity, delaying progression, and improving quality of life. Aim of the study: This study reviews PCa pathogenesis and evaluates the therapeutic potential of TCM through clinical efficacy data and mechanistic investigations. We further outline TCM's capacity to modulate PCa cellular dynamics through multi-scale biological interactions, establishing a framework for its application in PCa management. Our findings offer insights into TCM-based strategies for overcoming therapeutic limitations in prostate oncology. Materials and methods: This paper provides a systematic summary of PCa pathogenesis and analyzes the clinical efficacy and molecular mechanisms of TCM in treating PCa. Findings are based on searches using keywords such as 'prostate cancer,' 'pathogenesis,' 'Chinese herbal medicine,' 'herbal medicine,' 'traditional Chinese medicine,' and 'active components of Chinese medicine' in PubMed, Web of Science, EMBASE, Cochrane Library, Wanfang Database, and China National Knowledge Infrastructure (CNKI). Inclusion Criteria: (1) Original clinical studies, observational studies, RCTs, and meta-analyses related to the topic. (2) Articles published in the last 10 years on PCa treatment and mechanisms in TCM. (3) Studies investigating the mechanisms, treatment strategies, or efficacy of Chinese medicine in PCa. (4) Research on the molecular mechanisms, therapeutic effects, or potential of Chinese herbs or components for PCa. Exclusion Criteria: (1) Abstracts, conference proceedings, opinion pieces, or non-peer-reviewed articles. (2) Studies with low methodological quality (e.g., lacking control groups or detailed drug dosages). (3) Irrelevant studies or those focusing on unrelated diseases. Results: PCa pathogenesis involves gene mutations, androgen signaling abnormalities, epigenetic changes, inflammation, and metabolic reprogramming. TCM modulates the internal environment to delay progression, extend survival, improve quality of life, enhance immune defense, and alleviate chemotherapy and radiation side effects. TCM also inhibits tumor cell proliferation, metastasis, promotes apoptosis, regulates autophagy and ferroptosis, and reverses chemotherapy resistance, exerting anti-PCa effects through these pathways. Conclusions: PCa pathogenesis involves genetics, hormones, inflammation, and metabolism, and remains incompletely understood. TCM significantly inhibits PCa progression by regulating cell behavior, improving symptoms, and reducing adverse effects. However, large-scale, multi-center studies are needed to support its application.