文献类型：期刊文献

英文题名：Engineered Carbon Nanotube Scaffolds for Next-Generation Tissue Engineering: Synergizing Mechanical, Electrical, and Bioactive Properties-a Review

作者：Li, Yunfei[1,2];Zhou, Yigui[1,2];Xue, Yun[1];Sun, Ruilong[1,2];Tian, Yongzheng[1,2];Zhan, Longwen[1,2];Liu, Ruitang[1,2];Fan, Bo[1];Gao, Qiuming[1]

第一作者：Li, Yunfei;李燕飞;李玉方;李越峰

通信作者：Fan, B[1];Gao, QM[2]

机构：[1]Chinese Peoples Liberat Army, Hosp Joint Logist Support Force 940, Orthoped Ctr, Lanzhou 730050, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Lanzhou 730050, Peoples R China

第一机构：Chinese Peoples Liberat Army, Hosp Joint Logist Support Force 940, Orthoped Ctr, Lanzhou 730050, Gansu, Peoples R China

通信机构：[1]corresponding author), 940th Hosp Joint Logist Support Force, Peoples Liberat Army, Lanzhou, Peoples R China;[2]corresponding author), 940th Hosp, Orthoped Ctr, Joint Logist Support Force Peoples Liberat Army Ch, Lanzhou, Peoples R China.

年份：2025

卷号：20

起止页码：14131

外文期刊名：INTERNATIONAL JOURNAL OF NANOMEDICINE

收录：;Scopus(收录号：2-s2.0-105023291445);WOS:【SCI-EXPANDED(收录号:WOS:001626195900001)】；

基金：Natural Science Foundation of Gansu Province (25JRRA809) Gansu University of Traditional Chinese Medicine (YBXM-202415) .

语种：英文

外文关键词：carbon nanotube CNTs; carbon nanotube composites; growth factors; tissue engineering; scaffold

摘要：Carbon nanotubes (CNTs) and their composites exhibit considerable potential for application in tissue engineering, owing to their unique physical, chemical, and biological properties which render them ideal candidates for constructing biological scaffolds, facilitating tissue regeneration, and enhancing cellular functions. This review systematically examines the application of CNT-based scaffolds, with a focus on their synergistic mechanical, electrical, and bioactive properties. We discuss the fundamental characteristics of CNTs, including their mechanical strength, electrical conductivity, chemical modifiability, antimicrobial activity, and the central challenge of cytotoxicity. Strategies to mitigate cytotoxicity through functionalization and composite formation are elaborated. The review probes the enhanced biocompatibility, electrical properties, and mechanical performance of CNT composites, alongside their applications in bone, neural, and cardiac tissue engineering. A specific focus is placed on CNT scaffolds functionalized with growth factors, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), highlighting their role in promoting angiogenesis and osteogenesis. Finally, we summarize the current state of the field, address existing limitations-particularly regarding cytotoxicity and long-term safety-and suggest promising directions for future research, including the integration of photothermal therapy and the need for more comprehensive in vivo studies. This review aims to provide a balanced and critical perspective on the journey of CNT-based scaffolds from laboratory innovation to clinical reality.