文献类型：期刊文献

英文题名：LncRNA TINCR: An Irreplaceable Biological Target in Human Malignancies

作者：Jia, Dengke[1];He, Yaping[2];Zhang, Yawu[1,3,4]

第一作者：Jia, Dengke

通信作者：Zhang, YW[1]

机构：[1]Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou 73000, Peoples R China;[3]Lanzhou Univ, Hepatobiliary Pancreat Inst, Hosp 2, Lanzhou 730000, Peoples R China;[4]Lanzhou Univ, Dept Gen Surg, Hosp 2, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Dept Gen Surg, Hosp 2, Lanzhou 730000, Peoples R China.

年份：2024

外文期刊名：CURRENT MEDICINAL CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001230668200001)】；

基金：This study was co-financed by the Lanzhou University Second Hospital "Cuiying Science and Technology Innovation" Project (Grant no. CY2021-MS-B18 to YW Zhang).

语种：英文

外文关键词：LncRNA; TINCR; human malignancies; malignant tumor; metabolism; diagnosis; therapeutic target; biomolecular marker

摘要：Currently, malignant tumors increasingly affect young people, which has caused a catastrophic financial burden on people worldwide. lncRNA has gained considerable attention because of its importance in the early diagnosis and treatment of tumors. In addition, since terminal differentiation-induced ncRNA (abbreviated as TINCR) was reported in a Nature article, it has received focus on targeted therapy of tumors, especially in digestive system malignant tumors. This review aims to reveal and summarize its important molecular mechanisms in human malignancies. In this review, relevant research works involving the relationship between TINCR and human malignancies are gathered through systematic retrieval of PubMed. TINCR is expressed bidirectionally in human malignancies. TINCR functions primarily as a ceRNA in human malignancies, and it also functions at the transcriptional level. Moreover, lncRNA TINCR has the potential to become a novel biomolecular marker of human malignancies.