文献类型：期刊文献

中文题名：微生物-肠-脑轴与抑郁症中医药研究进展

英文题名：Advances in traditional Chinese medicine research of depression based on microbiota-gut-brain axis

作者：高丽波[1];黄生辉[2];唐珂[1];金华[3];张静霞[1]

第一作者：高丽波

机构：[1]甘肃中医药大学附属医院,甘肃兰州730000;[2]甘肃省中医院,甘肃兰州730050;[3]甘肃中医药大学,甘肃兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2020

卷号：47

期号：8

起止页码：2582

中文期刊名：微生物学通报

外文期刊名：Microbiology China

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：国家自然科学基金(81560716);甘肃省中医药管理局2018科研课题(GZK-2018-19);甘肃中医药大学附属医院院内课题(GZFY-2017-03);全国中医临床特色技术传承骨干人才培训项目。

语种：中文

中文关键词：肠道微生物;微生物-肠-脑轴;抑郁症;中医药

外文关键词：Gut microbiota;Microbiota-gut-brain axis;Depression;Traditional Chinese medicine

摘要：肠道微生物-肠-脑轴因其在调节精神疾病中的可能生物学基础作用而受到越来越多的关注。肠道微生物与抑郁症等精神疾病密切相关,肠道微生物可通过与"肠-脑轴"交互作用影响抑郁症的发生和发展,然而,肠道微生物与抑郁症之间的具体相互作用及机制还未十分明晰。深入研究微生物-肠-脑轴和抑郁症之间的相互关系,有助于我们从另一个角度更为深刻地认识和阐明抑郁症这种精神疾病。调节肠道微生物组成来治疗、预防抑郁症等精神疾病是今后的研究方向之一,可为探索中医药治疗、预防抑郁症机理提供新的思路。
The microbiota-gut-brain axis has received increasing attention due to its possible biological basis in regulating mental illness. The gut microbiota is closely related to neuropsychiatric diseases such as depression. It can affect the development of depression through interaction with the "gut-brain axis". However, the mechanism between gut microbiota and depression is not yet very clear. In-depth studies of the realtionship between microbiota-gut-brain axis and depression help us to recognize and understand the depression from another perspective. Regulating the composition of gut microbiota to treat and prevent neuropsychiatric diseases such as depression is one of the future research directions, which also provides new ideas for exploring the mechanism of Chinese medicine treatment and prevention of depression.