文献类型：期刊文献

中文题名：敦煌大宝胶囊对衰老模型大鼠脑组织氧自由基域影响的研究

英文题名：Study on Effect of DunHuangShiShiDaBao Capsule on Oxygen Free Radical Threshold in Brain Tissues of Senile Rats

作者：王联民[1];梁玉杰[2];段永强[2];朱立鸣[2];成映霞[2];明海霞[2]

第一作者：王联民

机构：[1]甘肃金昌市八冶医院,甘肃金昌737100;[2]甘肃中医学院基础课部,甘肃兰州737100

第一机构：甘肃金昌市八冶医院,甘肃金昌737100

年份：2009

卷号：15

期号：7

起止页码：506

中文期刊名：中国中医基础医学杂志

外文期刊名：JOURNAL OF BASIC CHINESE MEDICINE

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD_E2011_2012】；

基金：兰州市科技局计划项目(06-2-87);甘肃省科技攻关计划项目(2GS064-A43-020-22)

语种：中文

中文关键词：氧自由基域;衰老模型;敦煌石室大宝胶囊

外文关键词：oxygen free radical threshold ; aging model ; DunHuangShiShiDaBaoCapsule （DHDB）

摘要：目的:研究敦煌大宝胶囊对衰老模型大鼠脑组织氧自由基域影响的影响。方法:采用D-半乳糖颈后皮下注射的方法,造成亚急性衰老动物模型。将48只大鼠随机分为空白组、模型组、阳性对照组、中药大宝(大、中、小)剂量组,分别对各组大鼠脑组织GSH-Px、SOD、CAT活性和MDA、LPF含量进行检测。结果:与空白组比较,模型组大鼠脑组织GSH-Px、SOD、CAT活性显著下降(P<0.05,P<0.01,P<0.01),而MDA、LPF含量显著升高(P<0.05,P<0.05),提示造模成功。与模型组比较,敦煌石室大宝胶囊可显著升高SOD、GSH-Px、CAT活性(P<0.05,P<0.05,P<0.05),显著降低MDA、LPF含量(P<0.05,P<0.05)。结论:敦煌石室大宝胶囊具有提高机体抗氧化、清除自由基能力。
Objective： To study effects of DunHuangShiShiDaBaoCapsule（DHDB） on oxygen free radical threshold in brain tissues of senile rats. Methods：An aging rat model was established by adopting the method that rats were injected subcutaneously in nape with D-galactose. 48 rats were divided into 6 groups randomly： normal group, model group, positive control group, high dose of DHDB, middle dose of DHDB and low dose of DHDB. Then observed the effect of DHDB on levels of GSH-Px, SOD, CAT, LPF and MDA in brain tissue. Results：In successful model group, SOD, GSH-Px and CAT were much lower（ P 〈 0.05, P 〈 0.01, P 〈 0.01 ）, but LPF and MDA was much higher than those of normal group（ P 〈 0.05, P 〈 0.05）. Compared with model group, DHDB could not only obviously improve SOD, GSH-Px and CAT （ P 〈 0.05, P 〈 0.05, P 〈 0.05）, but also significantly decrease MDA and LPF in brain tissue of aging rats （ P 〈 0.05, P 〈 0.05 ）. Conclusion： It was suggested that DHDB has functions of improving body＇s resisting oxidation and eliminating free radicle.