文献类型：期刊文献

英文题名：Elucidating causal relationships of diet-derived circulating antioxidants and the risk of osteoporosis: A Mendelian randomization study

作者：Yuan, Kexin[1];Xie, Xingwen[2];Huang, Weiwei[1];Li, Dingpeng[3];Zhao, Yongli[2];Yang, Haodong[1];Wang, Xuetao[1]

第一作者：Yuan, Kexin

通信作者：Wang, XT[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[3]Second Peoples Hosp Gansu Prov, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：15

外文期刊名：FRONTIERS IN GENETICS

收录：;Scopus(收录号：2-s2.0-85196546607);WOS:【SCI-EXPANDED(收录号:WOS:001250817300001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by National Natural Science Foundation of China (82160911, 82374491), the third batch of provincial science and technology programs in 2023 (Basic Research Program-Natural Science Foundation - Excellent Doctoral Program) (23JRRA1226), Gansu excellent graduate student innovation star project (2023CXZX-732); and Gansu Top Talents (Science and Technology Territory) Training Support Fund Project [(2021) No. 2].

语种：英文

外文关键词：diet-derived antioxidants; oxidative stress; osteoporosis; bone mineral density; fractures; Mendelian randomization

摘要：Background Osteoporosis (OP) is typically diagnosed by evaluating bone mineral density (BMD), and it frequently results in fractures. Here, we investigated the causal relationships between diet-derived circulating antioxidants and the risk of OP using Mendelian randomization (MR).Methods Published studies were used to identify instrumental variables related to absolute levels of circulating antioxidants like lycopene, retinol, ascorbate, and beta-carotene, as well as antioxidant metabolites such as ascorbate, retinol, alpha-tocopherol, and gamma-tocopherol. Outcome variables included BMD (in femoral neck, lumbar spine, forearm, heel, total body, total body (age over 60), total body (age 45-60), total body (age 30-45), total body (age 15-30), and total body (age 0-15)), fractures (in arm, spine, leg, heel, and osteoporotic fractures), and OP. Inverse variance weighted or Wald ratio was chosen as the main method for MR analysis based on the number of single nucleotide polymorphisms (SNPs). Furthermore, we performed sensitivity analyses to confirm the reliability of the findings.Results We found a causal relationship between absolute retinol levels and heel BMD (p = 7.6E-05). The results of fixed effects IVW showed a protective effect of absolute retinol levels against heel BMD, with per 0.1 ln-transformed retinol being associated with a 28% increase in heel BMD (OR: 1.28, 95% CI: 1.13-1.44). In addition, a sex-specific effect of the absolute circulating retinol levels on the heel BMD has been observed in men. No other significant causal relationship was found.Conclusion There is a positive causal relationship between absolute retinol levels and heel BMD. The implications of our results should be taken into account in future studies and in the creation of public health policies and OP prevention tactics.