文献类型：期刊文献

英文题名：Preparation and MRI performances of core-shell structural PEG salicylic acid-gadolinium composite nanoparticles

作者：Zhang, Jia[1];Lin, Zhiyan[2];Zhao, Minzhi[1];Xu, Weibing[1];Nian, Fang[1]

第一作者：Zhang, Jia

通信作者：Xu, WB[1];Nian, F[1]

机构：[1]Gansu Agr Univ, Coll Sci, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Clin Med Coll, Lanzhou 730000, Peoples R China

第一机构：Gansu Agr Univ, Coll Sci, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Gansu Agr Univ, Coll Sci, Lanzhou 730000, Peoples R China.

年份：2022

卷号：40

期号：7

起止页码：1098

外文期刊名：JOURNAL OF RARE EARTHS

收录：;EI(收录号：20221812056350);Scopus(收录号：2-s2.0-85124582025);WOS:【SCI-EXPANDED(收录号:WOS:000822693500012)】；

基金：Project supported by the Natural Science Foundation of Gansu Province (20JR10RA511, 2019B-084)

语种：英文

外文关键词：Gadolinium; Salicylic acid; Polyethylene glycols; Core-shell structural; MRI contrast agent; Rare earths

摘要：Gadolinium (III)-based T1 contrast agents have been widely used in clinical MRI. In this study, salicylic acid-gadolinium chelate was prepared via directly coordination reaction of gadolinium ion and salicylic acid. Then, three polyethylene glycols with different molecular weight were modified on the surface of salicylic acid-gadolinium by simple chemical coupling to construct three core-shell structural Gd based composites. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterization results show that the composite is a spherical particle with a diameter of about 100-200 nm. The longitudinal relaxation rate r1 of the Gal-PEG-200 0 is 11.097 (mmol/L)-1/s, and the ratio of r2/r1 is as low as 2.53. The composite shows good liver and intestines MRI performances after being used in in vivo imaging, showing a good prospect of biological application.(c) 2021 The Authors. Published by Elsevier B.V. on behalf of Chinese Society of Rare Earths. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).