文献类型：期刊文献

英文题名：Applications of Tissue-Inducing Biomaterials in Nonosseous Tissues: Evidence Map of Animal Studies

作者：Liu, Yanli[1,2,3];Wu, Qiang[4];Zhao, Wanlu[5,6];Song, Xu[5,6,7];Ding, Fengxing[1,2,3];Du, Wanxian[1,2,3];Niu, Muting[8];Zhao, Yue[8];Yuan, Bo[5,6];Lin, Hai[5,6];Zhang, Kai[5,6,7];Ma, Bin[1,2,3]

第一作者：Liu, Yanli

通信作者：Ma, B[1];Yuan, B[2];Lin, H[2];Yuan, B[3];Lin, H[3]

机构：[1]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, 199 Donggang West Rd, Lanzhou 730000, Peoples R China;[2]Lanzhou Univ, Res Ctr Med Device Regulatory Sci, Lanzhou, Peoples R China;[3]Ind Ctr Evidence Based Res & Evaluat Stand Med Dev, Lanzhou, Peoples R China;[4]Lanzhou Univ, Hosp 2, Dept Cardiol, Lanzhou, Peoples R China;[5]Sichuan Univ, Coll Biomed Engn, 29 Wangjiang Rd, Chengdu 610065, Peoples R China;[6]Sichuan Univ, Natl Engn Res Ctr Biomat, 29 Wangjiang Rd, Chengdu 610064, Peoples R China;[7]Sichuan Univ, Inst Regulatory Sci Med Devices, Chengdu, Peoples R China;[8]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, 199 Donggang West Rd, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, 199 Donggang West Rd, Lanzhou 730000, Peoples R China;[2]corresponding author), Sichuan Univ, Coll Biomed Engn, 29 Wangjiang Rd, Chengdu 610065, Peoples R China;[3]corresponding author), Sichuan Univ, Natl Engn Res Ctr Biomat, 29 Wangjiang Rd, Chengdu 610064, Peoples R China.

年份：2025

外文期刊名：TISSUE ENGINEERING PART A

收录：;EI(收录号：20253519076485);Scopus(收录号：2-s2.0-105014413609);WOS:【SCI-EXPANDED(收录号:WOS:001565063000001)】；

基金：This work was supported by the National Key Research and Development Program of China (Grant number 2022YFC2409705) and the National Key Research and Development Program of China (Grant number 2022YFC2409803).

语种：英文

外文关键词：tissue-inducing biomaterials; nonosseous tissue repair; animal experiments; evidence mapping

摘要：Tissue-inducing biomaterials, which promote tissue regeneration without the addition of exogenous cells and/or bioactive factors, have recently attracted increasing interest in the repair of nonosseous tissues. As a key strategy for transforming data into actionable evidence, evidence-based biomaterials research plays a critical role in guiding material development. In this study, evidence mapping method was employed to systematically analyze and visualize animal study designs, material characteristics, outcome indicators, and evaluation methods, aiming to identify current research trends and emerging focal areas. The results revealed a wide diversity of experimental animal species, with a predominance of small animal models. Among the 19 types of nonosseous tissues investigated, skin, abdominal wall, cartilage, and blood vessels were the most frequently studied. Materials were mainly classified into bio-derived materials, polymers, and composites. Outcome indicators span from macroscopic to molecular levels, with tissue-level indicators being the most commonly applied. Histological analysis served as the primary method for validating inductive effects, supported by gross observation, imaging analysis, molecular biology assays, and biomechanical testing. Overall, tissue-inducing biomaterials show promising potential for nonosseous tissue regeneration. However, challenges remain, including limitations of animal models, short follow-up periods, and insufficient evaluation systems. Future studies should strengthen the alignment between functional validation and clinical needs to promote the translation of these materials from experimental research to clinical application.