文献类型：期刊文献

英文题名：Study on the expression of c-Met in gastric cancer and its correlation with preoperative serum tumor markers and prognosis

作者：Zhang, Zhengchao[1,2,3];Miao, Lele[1,2];Wang, Song[1,2];Zhao, Yang[1,2];Xie, Yongqiang[3];Yun, Heng[3];Ren, Zhijian[1,2];Wang, Guan[1,2];Teng, Muzhou[1,2];Li, Yumin[1,2]

第一作者：Zhang, Zhengchao

通信作者：Teng, MZ[1];Li, YM[1]

机构：[1]Lanzhou Univ, Dept Gen Surg, Hosp 2, Lanzhou 730000, Peoples R China;[2]Key Lab Digest Syst Tumors Gansu Prov, Lanzhou 730000, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Gen Surg, Lanzhou 730900, Peoples R China

第一机构：Lanzhou Univ, Dept Gen Surg, Hosp 2, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Key Lab Digest Syst Tumors Gansu Prov, Lanzhou 730000, Peoples R China.

年份：2022

卷号：20

期号：1

外文期刊名：WORLD JOURNAL OF SURGICAL ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85132243628);WOS:【SCI-EXPANDED(收录号:WOS:000812256900004)】；

基金：This research was funded by the Special Research Project of Lanzhou University Serving the Economic Social Development of Gansu Province (054000282), the Lanzhou Talent Innovation and Entrepreneurship Project (2020-RC-38), the Fundamental Research Funds for the Central Universities (lzujbky-2020-kb14), and the Major Science and Technology Special Project of Gansu Province (20ZD7FA003).

语种：英文

外文关键词：c-Met; Gastric cancer; CA125; AFP; Prognosis; Independent risk factors

摘要：Background Studies have found that c-Met plays a critical role in the progression of solid tumors. This study aimed to investigate the expression of c-Met in gastric cancer (GC) and its correlation with preoperative serum tumor markers and prognosis, in order to provide a more theoretical basis for targeting c-Met in the treatment of GC. Methods Ninety-seven patients who underwent curative gastrectomy in our hospital from December 2013 to September 2015 were included in this study. The tissue microarray was constructed by paraffin-embedded tumor tissue of enrolled patients, including 97 GC points and 83 paracancerous points. Then, it was used for c-Met immunohistochemical staining, followed by an immunological H-score. The clinical baseline data and 5-year survival of patients with low and high c-Met expression were compared. Besides, the correlation between the expression of c-Met in tumor tissues and preoperative serum tumor markers was investigated. Finally, multivariate Cox regression analysis was used to explore the survival risk factors of patients. Results c-Met has a high expression rate in GC tissues 64.95% (63/97). The expression of c-Met was significantly different in different clinicopathological stages (p < 0.05); the high expression group also had a higher M stage and clinicopathological stage of GC. The correlation test between the c-Met H-score and CA125 was statistically significant (p = 0.004), indicating a positive correlation. Furthermore, high c-Met expression correlated with poor overall survival (OS) for 5 years (p = 0.005). It was also found that the high expression of c-Met in stage I-II patients was correlative with poor OS for 5 years (p = 0.026), while stage III-IV patients had no statistical significance (p > 0.05). Multivariate Cox regression analysis showed that c-Met might be an independent risk factor for survival 5 years after surgery. Conclusion This study found that the high expression of c-Met in GC tissues was associated with poor 5-year OS in GC patients and was an independent risk factor for 5-year survival after curative gastrectomy. The expression of c-Met in GC tissues was also positively correlated with preoperative serum CA125.