文献类型：期刊文献

中文题名：生脉散对阿霉素大鼠心肌损伤的保护作用

英文题名：Protective effects of Shengmai San against myocardial damage induced by adriamycin in rats

作者：魏道武[1];李应东[1]

第一作者：魏道武

机构：[1]甘肃中医学院内科教研室,兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：1999

卷号：15

期号：4

起止页码：9

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：生脉散;心肌损伤;阿霉素;自由基

外文关键词：Shengmai San;adriamycin;myocardial damage;free radicals

摘要：阿霉素（ Ａ Ｄ Ｒ） 并ｉｇ 生脉散生药５ｇ／ｋｇ 组 大鼠阿 霉素毒 性症状 较之 Ａ Ｄ Ｒ 组 出现较 晚，发生 充血性心力衰竭例数较少，且心肌病理改变明显较轻。阿霉素对大鼠全血 Ｇ Ｓ Ｈ Ｐｘ 活性及心肌 Ｓ Ｏ Ｄ 活性有明显抑制作用，并可使心肌组织内 Ｍ Ｄ Ａ 含量增加。 Ａ Ｄ Ｒ 并服用 生脉散 组大鼠 全血 Ｇ Ｓ Ｈ Ｐｘ 、心肌 Ｓ Ｏ Ｄ 活性 较单用 阿霉素组增高，心肌 Ｍ Ｄ Ａ 含量较单用 Ａ Ｄ Ｒ 组大鼠减 少，提 示生脉散对阿霉素心肌毒性有对抗作用，其机理可能与其抗自由基反应有关。
The protective effects of Shengmai San against myocardial damage of adriamycin(ADR) in rats were studied.The results showed that the general toxic signs of ADR in Sengmai San group were occurred later than those in ADR group, the cases of congestive heart failure in Shengmai San group were less than that in ADR group, and the cardiac lesions were significantly milder in rats supplemented with Shengmai San than those received ADR only.The GSH Px activities in blood and the SOD activities in heart homogenates in Shengmai San group were significantly higher than that in ADR group (P<0.01).The MDA level in heart homogenates in Shengmai San group was significantly lower than that in ADR group (P<0.01).The results indicated that myocardial damage of ADR might be protected by Shengmai San treatment.These suggested that protective mechanism of Shengmai San to myocardial damage of ADR might be related to its antagonism on free radicals.