文献类型：期刊文献

英文题名：A wireless, position-insensitive electrical stimulation platform with adequate and configurable parameters for diverse therapeutic applications

作者：Ye, Zhilu[1];Wang, Yijing[1];Zhao, Kun[1];Zhao, Ganggang[2];Zhang, Yue[3];Xu, Zhe[1];Chen, Sicheng[4];Zhang, Qi[5];Liu, Ming[3];Zhang, Xiaohui[1]

第一作者：Ye, Zhilu

通信作者：Ye, ZL[1];Zhang, XH[1]

机构：[1]Xi An Jiao Tong Univ, Sch Life Sci & Technol, State Key Lab Mfg Syst Engn, Key Lab Biomed Informat Engn,Minist Educ, Xian, Shaanxi, Peoples R China;[2]Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA USA;[3]Xi An Jiao Tong Univ, Sch Elect Sci & Engn, State Key Lab Mfg Syst Engn, Elect Mat Res Lab,Key Lab,Minist Educ, Xian, Shaanxi, Peoples R China;[4]Xi An Jiao Tong Univ, Mech Engn Coll, Xian, Shaanxi, Peoples R China;[5]Gansu Univ Chinese Med, Sch Med Informat & Engn, Lanzhou, Gansu, Peoples R China

第一机构：Xi An Jiao Tong Univ, Sch Life Sci & Technol, State Key Lab Mfg Syst Engn, Key Lab Biomed Informat Engn,Minist Educ, Xian, Shaanxi, Peoples R China

通信机构：[1]corresponding author), Xi An Jiao Tong Univ, Sch Life Sci & Technol, State Key Lab Mfg Syst Engn, Key Lab Biomed Informat Engn,Minist Educ, Xian, Shaanxi, Peoples R China.

年份：2026

卷号：10

期号：1

外文期刊名：NPJ FLEXIBLE ELECTRONICS

收录：;Scopus(收录号：2-s2.0-105039581511);WOS:【SCI-EXPANDED(收录号:WOS:001771211000001)】；

基金：We acknowledge Wei Huang from the University of Electronic Science and Technology of China for reading the manuscript. We thank Ying Hao from the Instrumental Analysis Center of Xi'an Jiaotong University for assistance with the confocal microscope. This work was financially supported by the National Natural Science Foundation of China (Grant No. 62401454), the National Key Research and Development Program of China (2022YFB3206805HZ), and the supporting project (GXKJXM20230186).

语种：英文

摘要：Wireless electrical stimulation enables precise modulation of tissue activity through wirelessly delivered electrical pulses, providing a minimally invasive strategy for tissue repair and treatment of diverse pathological disorders. However, existing wireless stimulators suffer from low output voltages, strict alignment requirements, and disease-specific designs that constrain adaptability. Here, we present a wireless, battery-free electrical stimulation system offering misalignment tolerance, high-voltage capacity, and widely configurable parameters for diverse therapeutic applications. Utilizing inductive coupling and strategic radio-frequency circuit design, the system delivers stimulation voltages up to 15 V peak-to-peak and maintains output stability (+/- 3 V) under significant spatial and angular misalignment (+/- 18 mm lateral, +/- 15 mm vertical, and +/- 40 degrees angular). The system also provides configurable stimulation parameters, including amplitude (mV to similar to 10 V), frequency (Hz-kHz), and duty cycle (1-99%). We demonstrate its efficacy in two representative stimulation therapy scenarios, epidermal wound healing and peripheral nerve regeneration. In vitro studies show enhanced proliferation, migration, and neurite extension in relevant cell types, while in vivo experiments reveal a similar to 25% acceleration in wound healing and similar to 40% improvement in nerve regeneration over 4 weeks, with no observable adverse effects. These findings establish our system as a general-purpose, high-performance, cost-efficient solution for next-generation wireless bioelectronic therapies.