文献类型：期刊文献

英文题名：Multilevel regulation and molecular mechanism of poly (rC)-binding protein 1 in cancer

作者：Zhang, Xuetian[1,2,3,4];Di, Cuixia[1,2,3,4];Chen, Yuhong[1,2,3,4];Wang, Jing[5];Su, Ruowei[6];Huang, Guomin[1,2,3,4];Xu, Caipeng[1,2,3,4];Chen, Xiaohua[1,2,3,4];Long, Feng[7];Yang, Hongying[8];Zhang, Hong[1,2,3,4]

第一作者：Zhang, Xuetian

通信作者：Di, CX[1];Zhang, H[1]

机构：[1]Chinese Acad Sci, Inst Modern Phys, Biomed Res Ctr, Lanzhou, Gansu, Peoples R China;[2]Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China;[3]Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China;[4]Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing, Peoples R China;[5]Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China;[6]Xiamen Univ, Affiliated Hosp 1, Sch Med, Xiamen, Fujian, Peoples R China;[7]Gansu Univ Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[8]Med Coll Soochow, Sch Radiat Med & Protect, Suzhou, Peoples R China

第一机构：Chinese Acad Sci, Inst Modern Phys, Biomed Res Ctr, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Gansu, Peoples R China.

年份：2020

卷号：34

期号：12

起止页码：15647

外文期刊名：FASEB JOURNAL

收录：;Scopus(收录号：2-s2.0-85092512250);WOS:【SCI-EXPANDED(收录号:WOS:000581157600001)】；

基金：This work was supported by grants from the National Key R&D project of the Chinese Ministry of Science and Technology [2018YFE0205100]; the Key Program of the National Natural Science Foundation of China [U1632270]; the National Natural Science Foundation of China [11675234]; and the Natural Science Foundation of Gansu Province, China [17JR5RA310].

语种：英文

外文关键词：cancer therapy; gene expression; mechanisms; PCBP1; tumor suppressor

摘要：Poly (rC)-binding protein 1 (PCBP1), an RNA- or DNA-binding protein with a relative molecular weight of 38 kDa, which is characterized by downregulation in many cancer types. Numerous cases have indicated that PCBP1 could be considered as a tumor suppressor to inhibit tumorigenesis, development, and metastasis. In the current review, we described the multilevel regulatory roles of PCBP1, including gene transcription, alternative splicing, and translation of many cancer-related genes. Additionally, we also provided a brief overview about the inhibitory effect of PCBP1 on most common tumors. More importantly, we summarized the current research status about PCBP1 in hypoxic microenvironment, autophagy, apoptosis, and chemotherapy of cancer cells, aiming to clarify the molecular mechanisms of PCBP1 in cancer. Taken together, in-depth study of PCBP1 in cancer may provide new ideas for cancer therapy.