文献类型：期刊文献

英文题名：Brain morphology and functional connectivity alterations in patients with severe obstructive sleep apnea

作者：Gao, Jing[1];Cao, Jiancang[2];Chen, Jieyu[1];Wu, Dan[1];Luo, Ke[1];Shen, Guo[3];Fang, Yanyan[2];Zhang, Wenwen[2];Huang, Gang[2];Su, Xiaoyan[4];Zhao, Lianping[2]

第一作者：高娟

通信作者：Zhao, LP[1]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou 730000, Peoples R China;[2]Gansu Prov Hosp, Dept Radiol, Lanzhou 730000, Peoples R China;[3]Ningxia Med Univ, Sch Clin Med, Yinchuan 750004, Peoples R China;[4]Gansu Prov Hosp, Sleep Med Ctr, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Radiol, Lanzhou 730000, Peoples R China.

年份：2023

卷号：111

起止页码：62

外文期刊名：SLEEP MEDICINE

收录：;Scopus(收录号：2-s2.0-85171170055);WOS:【SCI-EXPANDED(收录号:WOS:001082266000001)】；

基金：This research was funded by the National Natural Science Foundation of China (No.81901724; No.81860306) , the "Young Scholars in Western China" project of the Chinese Academy of Sciences in 2020, the Natural Science Foundation of Gansu Province (No.20JR5RA156; No.21JR7RA593) , the Foundation of Gansu Provincial Hospital (19SYPYA-2) , Gansu Province outstanding Graduate Student Innovation Star Program (2022CXZX-742) .

语种：英文

外文关键词：Obstructive sleep apnea; Deformation-based morphometry; Functional connectivity; Resting-state functional magnetic resonance imaging; Cognition impairment

摘要：Background: It has been demonstrated that widespread structural and functional brain alterations influence the development of cognitive impairment in patients with obstructive sleep apnea (OSA). However, the literature has limited evidence regarding the neuropathophysiological mechanisms behind these impairments. This research aimed to investigate brain morphologic and functional connectivity (FC) abnormalities related to neurocognitive function in OSA.Methods: Fifty treatment-naive males, newly diagnosed patients with severe OSA, and 50 well-matched healthy controls (HCs) were enrolled prospectively. All subjects underwent an MRI scan, cognitive psychological and sleep scale assessment. The differences of brain morphological and seed-based FC between the two groups were compared. The correlation analysis and receiver operating characteristic curve were performed for further analysis.Results: Compared with HCs, the right brainstem, left dorsal-lateral superior frontal gyrus (SFGdor), and superior temporal gyrus (STG) exhibited atrophy in the OSA group. In addition, FC between the left SFGdor and the right postcentral gyrus (PoCG) was increased, which was positively correlated with disease duration (r = 0.312, FDR-corrected P = 0.027). The Jacobian values of the brainstem were negatively correlated with MoCA and recall scores (r = -0.449, FDR-corrected P = 0.0025; r = -0.416, FDR-corrected P = 0.005). Furthermore, the Jacobian values of the left SFGdor demonstrated a relatively high diagnostic performance (sensitivity: 86%, specificity: 56%, AUC: 0.740, 95% CI: 0.643-0.836, P < 0.0001).Conclusions: Structural atrophy in brainstem and frontotemporal lobe and altered FC may be the neurobiological hallmark of brain impairment in OSA. Notably, brainstem atrophy has been associated with cognitive impairment, which may provide new insights into understanding the neuropathophysiological mechanisms of cognitive impairment in OSA patients.