文献类型：期刊文献

中文题名：抗衰益智胶囊对衰老大鼠脑组织胆碱能神经递质及单胺类神经递质的影响

英文题名：Effects of Kangshuaiyizhi Capsule on Cholinergic and Monoamine Neurotransmitter in Brain Tissue of Aging Model Rats

作者：郑世铎[1];徐海荣[2];段永强[2];刘稼[2];朱向东[2];成映霞[2];杨晓轶[2];程容[2]

第一作者：郑世铎

机构：[1]甘肃中医学院附属医院;[2]甘肃中医学院

第一机构：甘肃中医药大学第二附属医院

年份：2013

卷号：20

期号：7

起止页码：33

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2013_2014】；

基金：甘肃省中医药管理局资助项目(W02-1)

语种：中文

中文关键词：胆碱能神经递质;单胺类神经递质;抗衰益智胶囊;大鼠

外文关键词：cholinergic neurotransmitter; monoamine neurotransmitter; Kangshuaiyizhi capsule; rats

摘要：目的观察抗衰益智胶囊对衰老模型大鼠脑组织胆碱乙酰转移酶/乙酰胆碱酯酶(ChAT/AchE)活性及去甲肾上腺素(NE)、多巴胺(DA)和5-羟色胺(5-HT)含量的影响,探讨其对衰老大鼠脑功能的保护作用。方法将受试动物按随机数字表法分为空白组和造模组。采用D-半乳糖(0.125 g/kg)皮下注射建立衰老模型并筛选符合衰老模型的大鼠,按随机数字表法分为模型组、脑复康组和抗衰益智胶囊大、小剂量组。各药物组予相应药物干预60 d后测定各组大鼠脑组织内ChAT/AchE活性及NE、DA和5-HT含量。结果与空白组比较,模型组大鼠脑组织内AchE活性升高,ChAT活性降低(P<0.05),NE、DA、5-HT含量降低(P<0.05)。与模型组比较,抗衰益智胶囊治疗组大鼠脑组织内AchE活性降低(P<0.05),ChAT活性升高(P<0.01),NE、DA、5-HT含量增高(P<0.05)。结论抗衰益智胶囊可调节衰老模型动物脑组织单胺类和胆碱能神经递质代谢而发挥保护脑功能的作用。
Objective To explore the effects of Kangshuaiyizhi capsule on ChAT/AchE and NE,DA and 5-HT levels in the brain tissue of aging model rats,and explore its effect of protecting cerebral function.Methods Totally 72 rats were randomly divided into normal group and model group.The subacutely aging model rats were made by injecting D-gal（0.125 g/kg） into abdominal cavity continually,then aging rats were divided by random number table into model group,Naofukang group and Kangshuaiyizhi high-,low-dose group.After intervented with correspongding drugs for 60 days,activity of ChAT and AchE,cerebral cortex NE,DA,and 5-HT levels were detected.Results Activity of AchE was much higher（P 0.05）,but level of ChAT,NE,DA and 5-HT in model group were significantly downregulated compared with normal group（P 0.05）.After treated with Kangshuaiyizhi capsule,activity of AchE was downregulated,ChAT,NE,DA and 5-HT levels were significantly upregulated（P 0.01,P 0.05）.Conclusion Kangshuaiyizhi capsule can regulate cholinergic and monoamine neurotransmitter levels in the brain tissue of aging model rats,and play a very important role in protecting cerebral function.