文献类型：期刊文献

中文题名：帕金森病模型大鼠的氧化应激反应及绿茶多酚的干预作用

英文题名：Oxidative Stress Reaction of the Rat Models with Parkinson′s Disease and the Intervention Effects of Green Tea Polyphenols

作者：梁建庆[1];何建成[2]

第一作者：梁建庆

机构：[1]甘肃中医药大学基础医学院;[2]上海中医药大学基础医学院

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）

年份：2017

卷号：30

期号：7

起止页码：4

中文期刊名：西部中医药

外文期刊名：Western Journal of Traditional Chinese Medicine

收录：CSTPCD

基金：国家自然科学基金(编号81573899;81660767);敦煌医学与转化省部共建教育部重点实验室开放课题(编号DHYX1516-08);上海市科委新药开发研究项目(编号12401900302);甘肃中医药大学中青年科研基金(编号ZQ2015-17)

语种：中文

中文关键词：帕金森病;氧化应激;绿茶多酚;大鼠

外文关键词：Parkinson＇s disease; oxidative stress; green tea polyphenols; the rats

摘要：目的:探讨帕金森病大鼠氧化应激反应及绿茶多酚的干预作用。方法:采用6-羟基多巴胺(6-OHDA)偏侧损毁纹状体制备帕金森病大鼠模型,并随机分为模型组、绿茶多酚组,另取正常对照组、假手术组大鼠,每组10只。分别在6周后进行神经行为学检测后,取纹状体,应用比色法分别测定各组大鼠纹状体内超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)的含量。结果:帕金森病模型组大鼠纹状体内SOD、GSH、GSH-Px的含量均明显减少,MDA含量呈增加趋势;而绿茶多酚组大鼠纹状体内SOD、GSH、GSH-Px的含量均呈现增加趋势,MDA含量呈减少趋势。结论:绿茶多酚能较好地改善帕金森病大鼠的氧化应激反应,可能通过清除自由基,减轻对细胞的损伤,从而缓解帕金森病的症状。
Objective： To discuss oxidative stress reactions of the rats with Parkinson＇s disease and the intervention of green tea polyphenols. Methods： Rat model with Parkinson＇s disease was prepared by 6-OHDA damaging corpus striatum unilaterally, and they were randomized into the model group and green tea polyphenols group, normal control group and sham operation group were established, ten rats each group. After detecting neuroethology in six weeks respectively, the contents of SOD, MDA, GSH, GSH-Px in corpus striatum of the rats were measured respectivelyby using colorimetry. Results： The contents of SOD, GSH and GSH-Px in the model group of Parkinson＇s disease lowered obviously, the contents of MDA showed a rise tendency, while the contents of SOD, GSH and GSH-Px in the green tea polyphenols group showed a rise tendency, while the contents of MDA demonstrated a decrease tendency. Conclusion： Green tea polyphenols could improve oxidative stress reactions of the rats with Parkinson＇s disease, and it could relieve the symptoms of Parkinson＇s disease by eliminating free radicals and relieving cellular damage.