文献类型：期刊文献

中文题名：PI3K/Akt信号通路在胃癌前病变中的作用及中药干预研究进展

英文题名：Research status of PI3K/Akt signaling pathway in precancerous lesions of gastric cancer and traditional Chinese medicine intervention

作者：豆鹏程[1];常晟[2];宋瑞平[3];左娇娇[1];封壮壮[4];陈心怡[5];王晓龙[1];舒劲[3]

第一作者：豆鹏程

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730030;[2]甘肃中医药大学继续教育学院,甘肃兰州730030;[3]甘肃省中医院脾胃病诊疗中心,甘肃兰州730050;[4]甘肃省中医院临床教学部,甘肃兰州730050;[5]甘肃省中医院药物临床试验中心,甘肃兰州730050

第一机构：甘肃中医药大学中医临床学院

年份：2025

卷号：41

期号：18

起止页码：2679

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金资助项目(82060860);甘肃省自然科学基金资助项目(21JR7RA588)。

语种：中文

中文关键词：中药;胃癌前病变;磷脂酰肌醇-3激酶/蛋白激酶B信号通路

外文关键词：traditional Chinese medicine;precancerous lesions of gastric cancer;phosphatidylinositol-3 kinase/protein kinase B signaling pathway

摘要：胃癌的高发病率和死亡率严重影响和威胁着公众的生命健康。胃癌前病变(PLGC)是胃黏膜癌变过程中的关键阶段,亦是胃癌形成前的“黄金转折点”,对其进行早期有效干预已成为当下胃癌防控的重要途径和研究重点。磷脂酰肌醇-3激酶(PI3K)/蛋白激酶B(Akt)信号通路参与炎症反应、血管生成、自噬水平、细胞凋亡等多种生物学过程,研究证实,该通路在PLGC中被异常激活,能够通过调控多种作用途径加促疾病向胃癌的恶性进展,可以被作为PLGC防治的潜在靶点和有效途径。近年来,中药通过靶向调控PI3K/Akt信号通路延缓甚或逆转PLGC取得了诸多研究成果。本文以PI3K/Akt信号通路为切入点,系统阐述了该信号通路在PLGC中的作用及中药干预研究进展,以期为本病临床治疗和药物研发与应用提供参考。
The high morbidity and mortality of gastric cancer seriously affect and threaten the public's life and health.Precancerous lesions of gastric cancer(PLGC)is a key stage in the process of gastric mucosal carcinogenesis,and it is also a"golden turning point"before the formation of gastric cancer.Early and effective intervention has become an important way and research focus for the prevention and control of gastric cancer.Phosphatidylinositol-3 kinase(PI3K)/protein kinase B(Akt)signaling pathway is involved in a variety of biological processes such as inflammatory response,angiogenesis,autophagy level and apoptosis.Studies have confirmed that this pathway is abnormally activated in PLGC and can promote the malignant progression of the disease to gastric cancer by regulating a variety of pathways,which can be used as a potential target and effective way for the prevention and treatment of PLGC.In recent years,traditional Chinese medicine has achieved many research results in delaying or even reversing PLGC by targeting the PI3K/Akt signaling pathway.Based on the PI3K/Akt signaling pathway,this paper systematically expounds the role of this signaling pathway in PLGC and the research progress of traditional Chinese medicine intervention,in order to provide reference for the clinical treatment of this disease and drug development and application.