文献类型：期刊文献

中文题名：慢性阻塞性肺疾病不同表型与中医证型的相关性研究

英文题名：Correlation Study between Clinical Phenotypes of Chronic Obstructive Pulmonary Disease and TCM Patterns

作者：韩敏娟[1];曹鹏鹏[1];胡建明[2];冯涛[2];孙杰[1]

第一作者：韩敏娟

机构：[1]甘肃中医药大学;[2]兰州大学第一医院

第一机构：甘肃中医药大学

年份：2016

卷号：0

期号：3

起止页码：63

中文期刊名：西部中医药

外文期刊名：Western Journal of Traditional Chinese Medicine

收录：CSTPCD

基金：甘肃中医学院创新基金项目(编号2014CX10)

语种：中文

中文关键词：慢性阻塞性肺疾病;表型;中医证型;相关性

外文关键词：chronic obstructive pulmonary disease;;phenotypes;;TCM patterns;;the correlation

摘要：目的:分析慢性阻塞性肺疾病(COPD)稳定期患者的临床表型和中医证型,研究其相关性。方法:将COPD患者268例参照文献,将其临床表型分为支气管壁增厚型、肺气肿型、混合型;同时根据指南将中医证型分为肺气虚证、肺脾气虚证、肺肾气虚证、肺肾气阴两虚证。采用关联性研究分析临床表型与中医证型的相关性,采用复试条图描述中医证型占临床表型的分布频率。结果:临床表型和中医证型具有关联性(χ2=17.793,r=0.25),差异具有统计学意义(P<0.01);支气管壁增厚型以肺脾气虚和肺肾气阴两虚为主,各占27.586%,47.126%;肺气肿型以肺脾气虚和肺肾气虚占多数,分别占39.241%,32.911%;混合型以肺脾气虚和肺肾气阴两虚为主,分别占34.314%,40.196%。结论:COPD临床表型和中医证型相关性强,对临床治疗有指导意义。
Objective: To study the correlation between clinical phenotypes of chronic obstructive pulmonary disease(COPD) and TCM patterns by analyzing clinical phenotypes and TCM patterns. Methods: According to the literature, clinical phenotypes of 268 COPD patients were divided into the types of bronchial wall thickening, pulmonary emphysema and mixed; simultaneously, it could be allocated to the patterns of pulmonary Qi-deficiency,lung-spleen Qi-deficiency, lung-kidney Qi-deficiency and dual Qi and Yin deficiency of lung-kidney according to the guidelines. The relationship between clinical phenotypes and TCM patterns was statistically analyzed by association study, and distribution frequency of TCM patterns occupied in clinical phenotypes was described by compound bar chart. Results: Clinical phenotypes showed significant correlation to TCM patterns( χ2=17.793, r=0.25), and the difference has statistical meaning(P<0.01); COPD of bronchial wall thickening types were usually lung-spleen Qi-deficiency and dual Qi and Yin deficiency of lung-kidney mainly, which held 27.586% and 47.126% respectively;COPD of pulmonary emphysema types were mostly lung-spleen Qi-deficiency and lung-kidney Qi-deficiency patterns, which occupied 39.241% and 32.911% respectively; mixed COPD were mainly lung-spleen Qi-deficiency and lung-kidney Qi-deficiency patterns, which held 34.314% amd 40.196% respectively. Conclusion: Clinical phenotypes of COPD are strongly correlated to TCM patterns, which are instructive in clinical treatment.