文献类型：期刊文献

英文题名：Correlation Between the MTHFR C677T Genotype and Coronary Heart Disease in Populations from Gansu, China

作者：Wu, Xue[1,2,3,4];Liu, Kai[1,3,5];Zhao, Xinke[1,3,5];Zhang, Xiaowei[2];Guo, Huan[1];Jiang, Hugang[1];Chang, Juan[1];Lv, Xinfang[1,5];Gao, Xiang[1,5];Zhi, Xiaodong[1,5];Ren, Chunzhen[1];Chen, Qilin[1];Liang, Yufang[2];Li, Yingdong[1,3,5,6]

第一作者：Wu, Xue

通信作者：Li, YD[1]

机构：[1]Gansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]Lanzhou Univ, Dept Cardiol, Hosp 2, Lanzhou, Peoples R China;[3]Univ Hosp Gansu Tradit Chinese Med, Key Lab Prevent & Treatment Chron Dis Tradit Chine, Lanzhou, Peoples R China;[4]Lanzhou Univ, Clin Med Coll 2, Lanzhou, Peoples R China;[5]Gansu Univ Chinese Med, Dept Cardiol, Affiliated Hosp, Lanzhou, Peoples R China;[6]Gansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, 35 Dingxi East Rd, Lanzhou 730030, Peoples R China

第一机构：甘肃中医药大学中西医结合学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, 35 Dingxi East Rd, Lanzhou 730030, Peoples R China.|[10735ed249c6606940a33]甘肃中医药大学中西医结合学院;[10735]甘肃中医药大学;

年份：2022

卷号：41

期号：11

起止页码：981

外文期刊名：DNA AND CELL BIOLOGY

收录：;Scopus(收录号：2-s2.0-85141891656);WOS:【SCI-EXPANDED(收录号:WOS:000877098200001)】；

基金：This study was funded by a research project grant from the Major Science and Technology special project of Gansu Province (20ZD7FA002), The TCM prevention and Treatment of major diseases scientific research project (GZKZD-2018-02), The Science and Technology Department of Gansu Province (21JR7RA399), The Lanzhou Science and Technology Bureau (2018-3-46, 2018-ZD-1), and the Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital (CY2021-BJ-A17).

语种：英文

外文关键词：coronary heart disease; homocysteine; methylenetetrahydrofolate reductase; folate

摘要：This study was designed to evaluate the relationship between polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and coronary heart disease (CHD) in populations from the Gansu region of China. The MTHFR C677T polymorphism genotypes from 209 patients with CHD, as confirmed by coronary angiography, and 212 non-CHD control patients were identified using PCR gold magnetic particle chromatography. We simultaneously evaluated homocysteine (Hcy) and folate levels in these samples using biochemical methods. The TT genotype of the MTHFR C677T locus was significantly more frequent in the CHD group than in the control, while the CC genotype was significantly less frequent in CHD patients than in non-CHD patients (p < 0.05). In addition, biochemical analysis revealed that the serum Hcy levels increased, and folate levels decreased in the TT genotype. Logistic regression analysis showed that this correlation was independent of nationality, sex, age, body mass index, medical history, and blood lipid level (p < 0.05). The occurrence of the TT genotype at the MTHFR C677T locus was closely associated with CHD in the Gansu population and may serve as a biomarker of increased risk for this disease.