文献类型：期刊文献

英文题名：Construction of azaspirocyclic skeletons mediated by the carbonyl of the Weinreb amide: formal total synthesis of (±)-cephalotaxine

作者：Liu, Jianyin[1];Zhang, Jian[1,2];Fan, Yuxue[1];Ding, Huili[1];Liu, Tianfu[1];Li, Shanshan[1];Jiang, Minghua[1];Liu, Lu[1]

第一作者：Liu, Jianyin

通信作者：Zhang, J[1];Zhang, J[2]

机构：[1]Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[2]Coll Gansu Prov, Key Lab Chem & Qual TCM, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Coll Gansu Prov, Key Lab Chem & Qual TCM, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：20

期号：9

起止页码：1879

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20221111772862);Scopus(收录号：2-s2.0-85125554423);WOS:【SCI-EXPANDED(收录号:WOS:000755221400001)，CCR-EXPANDED(收录号:WOS:000755221400001)】；

基金：This work was supported by the National Natural Science Foundation of China (21562001) and the Educational Science and Technology Innovation Program of Gansu Province (2021CYZC-13).

语种：英文

外文关键词：Musculoskeletal system - Synthesis (chemical)

摘要：A facile Stevens rearrangement of the Weinreb amide and the subsequent key steps mediated by the carbonyl of the Weinreb amide led to the construction of azaspirocyclic skeletons of some typical alkaloids. And the formal total synthesis of (+/-)-cephalotaxine was completed via a shorter synthetic route by this efficient method. Further studies on the development and asymmetric synthesis application of this strategy are underway.