详细信息
黄芪甲苷的提取、分离、纯化及其药理作用的研究进展 被引量:26
Research progress on extraction,separation and purification of astragaloside Ⅳ and its pharmacological effects
文献类型:期刊文献
中文题名:黄芪甲苷的提取、分离、纯化及其药理作用的研究进展
英文题名:Research progress on extraction,separation and purification of astragaloside Ⅳ and its pharmacological effects
作者:赵小强[1];赵静[1];张浩波[1];张义福[1]
第一作者:赵小强
机构:[1]甘肃中医药大学药学院,甘肃兰州730000
第一机构:甘肃中医药大学药学院(西北中藏药协同创新中心办公室)
年份:2022
卷号:37
期号:6
起止页码:711
中文期刊名:华西药学杂志
外文期刊名:West China Journal of Pharmaceutical Sciences
收录:CSTPCD;;CSCD:【CSCD_E2021_2022】;
基金:甘肃省教育厅创新基金项目(2022A-070);甘肃中医药大学扶贫科研项目(2019FPZX-4);甘肃省就业创业研究课题阶段性研究成果(2021-50)。
语种:中文
中文关键词:中药;黄芪甲苷;提取;分离;纯化;纯度;药理作用;研究进展;应用;吸收、代谢、分布、排泄过程
外文关键词:Traditional Chinese Medicine;Astragaloside IV;Extraction;Separation;Purification;Pharmacological action;Purity;The research progress;Application;ADMET
摘要:黄芪是甘肃的道地药材之一,应用十分广泛,为临床常用中药。黄芪甲苷是黄芪的主要活性成分之一,具有保护心脏、抗氧化、抗炎,抗肿瘤、抗细胞凋亡及调节血糖等药理作用。不同的提取、分离、纯化方法会对黄芪甲苷的含量和纯度产生不同程度的影响,进而影响药理作用的发挥。通过查阅和梳理国内外相关文献,对黄芪甲苷的提取、分离、纯化以及药理作用进行了综述,可为黄芪甲苷的研究提供参考。
Astragalus membranaceus is one of the genuine medicinal materials in Gansu province.It is widely used in clinic.Astragaloside IV is one of the main active components of Astragalus membranaceus,which has the pharmacological effects of heart protection,anti-oxidation,anti-inflammation,anti-tumor,anti-apoptosis and blood glucose regulation.Different extraction,separation and purification methods affect the content and purity of astragaloside IV to different degrees,and then affect the efficacy of pharmacological effects.This paper reviews the extraction,purification and pharmacological action of astragaloside IV by referring to and sorting out relevant literatures at home and abroad,so as to provide relevant reference for further study of astragaloside IV in the future.
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