文献类型：期刊文献

英文题名：Danggui Buxue Decoction Alleviates Acute Hypoxia-Induced Sleep Disorders: Insights from in vivo and in silico Analyses

作者：Zhou, Shihong[1];Chen, Dandan[1];Wang, Shuwei[1];Jiang, Xiaolin[2,3];Li, Jiangnan[2,3];He, Jianzheng[2,3,4];Xiu, Minghui[1,4]

第一作者：周守慧

通信作者：Xiu, MH[1];He, JZ[2];He, JZ[3];He, JZ[4];Xiu, MH[4]

机构：[1]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[4]Minist Educ, Key Lab Dunhuang Med, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[4]corresponding author), Minist Educ, Key Lab Dunhuang Med, Lanzhou 730000, Peoples R China.|[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;[10735]甘肃中医药大学;[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;

年份：2025

卷号：19

起止页码：6925

外文期刊名：DRUG DESIGN DEVELOPMENT AND THERAPY

收录：;Scopus(收录号：2-s2.0-105012971572);WOS:【SCI-EXPANDED(收录号:WOS:001548029300001)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 82360896), Gansu High Education Innovation Ability Improvement Project (No. 2023A-086), Open Fund Project of the Collaborative Innovation Center for Traditional Chinese Medicine Prevention and Control of Nutrition and Environment Related Diseases in Northwest China (No. ZYXT-24-06), Gansu Province Science Foundation for Youths (No. 24JRRA556).

语种：英文

外文关键词：Danggui Buxue decoction; acute hypoxia-induced sleep disorder; neuroprotective mechanism; active ingredients; Drosophila melanogaster

摘要：Background: Acute hypoxia-induced sleep disorders (AHISD) frequently occur in individuals exposed to high altitudes, yet current treatment options are limited. Danggui Buxue decoction (DBD) originated from the ancient medical book "NeiWaiShangBianHuo Lun" for more than 700 years, and is widely used to treat anemic diseases in clinical, with the potential to treat AHISD. Methods: We employed a combination of behavioral assays, transcriptomics, neurotransmitter profiling, and in-silico approaches to evaluate the effects and mechanisms of DBD. Results: DBD supplementation significantly alleviated sleep disorders in AHISD fruit flies, restoring the sleep time and the sleep structure. Mechanistically, DBD alleviated AHISD mainly by restoring neurotransmitter balance such as Glutamine (Gln) and Glutamic acid (Glu), modulating serotonin receptors (5-HT1A/1B), and suppressing neuroinflammatory Toll and Imd pathways. In addition, resveratrol, magnolol, and caffeic acid as the main active ingredients of DBD played an important role in alleviating AHISD. Conclusion: These findings suggest DBD as a promising candidate for mitigating AHISD through neuroprotective and antiinflammatory mechanisms.