文献类型：期刊文献

英文题名：Clinicopathological and prognostic significance of PD-L1 expression in colorectal cancer: a meta-analysis

作者：Wang, Shuxia[1];Yuan, Bo[2];Wang, Yun[1];Li, Mingyang[1];Liu, Xibo[1];Cao, Jing[1];Li, Changtian[2];Hu, Jihong[3]

第一作者：王世贤

通信作者：Hu, JH[1]

机构：[1]Gansu Univ Chinese Med, Publ Hlth Sch, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Basic Med Sch, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Ctr Res & Expt, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Ctr Res & Expt, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2021

卷号：36

期号：1

起止页码：117

外文期刊名：INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

收录：;Scopus(收录号：2-s2.0-85090780898);WOS:【SCI-EXPANDED(收录号:WOS:000568146000001)】；

基金：The research project was funded and supervised by the National Natural Science Foundation of China (NO.81960614).

语种：英文

外文关键词：Programmed death ligand-1 (PD-L1); Colorectal cancer (CRC); Prognosis; Clinicopathological features; Meta-analysis

摘要：Purpose To systematically evaluate the correlation between PD-L1 expression and clinicopathological features and prognosis of colorectal cancer (CRC). Methods Seven databases (PubMed, Cochrane Library, EMBASE, Web of Science, CBM, Wanfang, and CNKI) were searched through May 2020. Risk of bias and quality of evidence were assessed by using the Newcastle-Ottawa scale (NOS), and meta-analysis was carried out by using the Review Manager 5.3 software on the studies with the quality evaluation scores >= 6. Meta-regression analysis was used to determine the independent role of PD-L1 expression on CRC prognosis after adjusting clinicopathological features and treatment methods. Results A total of 8823 CRC patients in 32 eligible studies. PD-L1 expression was correlated with lymphatic metastasis (yes/no; OR = 1.24, 95% CI (1.11, 1.38)), diameter of tumor (>= 5 cm/< 5 cm; OR = 1.34, 95% CI (1.06, 1.70)), differentiation (high-middle/low; OR = 0.68, 95% CI (0.53, 0.87)), and vascular invasion (yes/no; OR = 0.80, 95% CI (0.69, 0.92)). PD-L1 expression shortened the overall survival (hazard ratio (HR) = 1.93, 95% CI (1.66, 2.25)), disease-free survival (HR = 1.76, 95% CI (1.50, 2.07)), and progression-free survival (HR = 1.93, 95% CI (1.55, 2.41)). Meta-regression showed that PD-L1 expression played a significant role on poor CRC OS (HR = 1.95, 95% CI (1.92, 3.98)) and disease-free survival (HR = 2.14, 95% CI (0.73, 4.52)). Conclusion PD-L1 expression independently predicted a poor prognosis of CRC.