文献类型：期刊文献

中文题名：Box-Behnken设计-效应面法优选蒲黄干法制粒工艺

英文题名：Optimization of Dry Granulation Technology of Typha Pollen Granules by Box-Behnken Design and Response Surface Method

作者：范凌云[1];余琰[1];高建德[1];金辉[1]

第一作者：范凌云

机构：[1]甘肃中医药大学,甘肃省高校中(藏)药化学与质量研究省级重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

年份：2018

卷号：25

期号：1

起止页码：84

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2017_2018】；

基金：甘肃省自然科学基金(1508RJZA010)

语种：中文

中文关键词：蒲黄;Box-Behnken设计-效应面法;干法制粒

外文关键词：Typhae Pollen; Box-Behnken design-response surface method; dry granulation

摘要：目的优选蒲黄干法制粒工艺。方法以颗粒得率和脆碎度为评价指标,以药粉含水量、压片变频、制粒变频为考察因素,采用单因素试验考察各因素对指标的影响程度,采用Box-Behnken设计考察各因素对评价指标总评OD值的影响,并采用效应面法预测、分析、优化最佳工艺。结果最佳干法制粒工艺为药粉含水量35.0%,压片变频27 Hz,制粒变频15 Hz。结论所选工艺稳定、可行、重现性好,可用于蒲黄的制粒。
Objective To optimize the dry granules process of Typha Pollen.Methods The particle size and particle friability were selected as evaluation indexes.The inspect factors were water content,compression frequency,and granulation frequency.Influence of inspect factors on evaluation indexes was investigated by single factor test,the influence of inspect factors on OD value was investigated by Box-Behnken design,and response surface method was adopted to predict,analyze and choose optimal process.Results The optimal dry granulation technology was as follows:the water content was35.0%;the frequency of tabletting was27Hz;the granulating frequency was15Hz.Conclusion The selected process is stable,feasible and reproducible,which can be used for granulation of Typha Pollen granules.