文献类型：期刊文献

英文题名：Salidroside Induces Apoptosis in Human Gastric Cancer Cells via the of ENO1/PKM2/GLUT1 Expression

作者：Dai, Ziying[1];Zhang, Xuan[2,3];Li, Wuyan[4];Tang, Junxia[1];Pan, Tingting[1];Ma, Chenru[1];Guan, Quanlin[5,6]

第一作者：Dai, Ziying

通信作者：Guan, QL[1];Guan, QL[2]

机构：[1]Lanzhou Univ, Clin Med Collage 1, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sci Res & Expt Ctr, Lanzhou 730000, Gansu, Peoples R China;[4]Temple Univ, Sch Med, Ctr Inflammat Translat & Clin Lung Res, Philadelphia, PA 19140 USA;[5]Lanzhou Univ, Hosp 1, Lanzhou 730000, Gansu, Peoples R China;[6]Lanzhou Univ, Key Lab Gastrointestinal Dis Gansu Prov, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Clin Med Collage 1, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Hosp 1, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, Key Lab Gastrointestinal Dis Gansu Prov, Lanzhou 730000, Gansu, Peoples R China.

年份：2021

卷号：44

期号：11

起止页码：1724

外文期刊名：BIOLOGICAL & PHARMACEUTICAL BULLETIN

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000741666600001)】；

基金：The authors thank the Central laboratory of the First Hospital of Lanzhou University for assisting with the experiments. This study was supported by the Key Technologies Research and Development Program (CN) (2017YFC0908302).

语种：英文

外文关键词：salidroside; gastric cancer; glycolysis; enolase 1 (ENO1); pyruvate kinase isoenzyme M2 (PKM2); glucose transporter 1 (GLUT1)

摘要：Salidroside is reported to have a wide range of pharmacological properties and has been proven to play a key anti-cancer effect. This study investigated the effects of purified salidroside, an ingredient of Rhodiola rosea, on the proliferation of two human gastric cancer cell lines and further investigating its possible molecular mechanisms. We verified that salidroside exerts a dose-dependent inhibitory effect on the proliferation of SGC-7901 and MKN-45 human gastric cancer cells. Moreover, salidroside can induce cell apoptosis, which was accompanied by an increase in nuclear fragmentation. In addition, salidroside inhibited glycolysis, as evidenced by the reduced expression levels of the glycolysis-related enzymes pyruvate kinase isoenzyme M2 (PKM2), enolase 1 (ENO1) and glucose transporter 1 (GLUT1), which could play important roles in the metabolism of gastric cancer cells. Further investigation showed that salidroside exerted potent anti proliferative effects by inhibiting glycolysis in human gastric cancer cells in vitro. In vivo, xenograft tumors treated with salidroside were significantly smaller than those in the control animals. Therefore, salidroside could be a promising therapeutic prospect in the treatment of gastric cancer.