文献类型：期刊文献

英文题名：Resting-State Brain Function Alteration in Colorectal Cancer Patients

作者：Xu, Yanan[1];Ma, Zihan[1];Chen, Jieyu[1];Zhang, Huiyan[2];Shen, Guo[2];Huang, Gang[3];Zhang, Wenwen[3];Zhao, Lianping[3]

第一作者：Xu, Yanan

通信作者：Zhao, LP[1]

机构：[1]Gansu Univ Tradit Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Ningxia Med Univ, Sch Clin Med, Yinchuan 750000, Ningxia, Peoples R China;[3]Gansu Prov Hosp, Dept Radiol, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Radiol, Lanzhou 730000, Gansu, Peoples R China.

年份：2024

卷号：23

期号：8

外文期刊名：JOURNAL OF INTEGRATIVE NEUROSCIENCE

收录：;Scopus(收录号：2-s2.0-85201751551);WOS:【SCI-EXPANDED(收录号:WOS:001302780500008)】；

基金：This work was supported by the Natural Science Foundation of Gansu Province (No. 23JRRA1772).

语种：英文

外文关键词：colorectal cancer; degree centrality; amplitude of low-frequency fluctuations; regional homogeneity; functional brain activity

摘要：Background and Purpose: To investigate the abnormal pattern of altered functional activity in the brain and the neuroimaging mechanisms underlying the cognitive impairment of patients with colorectal cancer (CRC) via resting-state functional magnetic resonance imaging (rs-fMRI). Materials and Methods: CRC patients (n = 56) and healthy controls (HCs) (n = 50) were studied. The participants underwent rs-fMRI scans and the Montreal Cognitive Assessment (MoCA). The amplitude of low-frequency fluctuations (ALFF), degree centrality (DC), regional homogeneity (ReHo), and MoCA scores, were calculated for participants. Results: The scores of executives, visuospatial, memory, language and attention were lower in CRC patients. ReHo and ALFF values in the left postcentral gyrus, ReHo values in the right postcentral gyrus, ALFF and DC values in the left middle occipital gyrus, ReHo and DC values in the right lingual gyrus, DC values in the right angular gyrus and precuneus, and ALFF values in the left middle temporal gyrus decreased conspicuously in the CRC patients. Conclusion: CRC patients have abnormal resting state function, mainly in the brain areas involved in cognitive function. The overlapping brain regions with abnormal functional indicators are in the middle occipital gyrus, postcentral gyrus, and lingual gyrus. This study reveals the potential biological pathways involved in brain impairment and neurocognitive decline in patients with CRC.