文献类型：期刊文献

英文题名：Research progress on the antitumor effects of harmine

作者：Hu, Yonghua[1,2,3,4];Yu, Xiaoli[3];Yang, Lei[3];Xue, Gaimei[3];Wei, Qinglin[4];Han, Zhijian[1,2];Chen, Hao[1,2]

第一作者：呼永华;Hu, Yonghua

通信作者：Han, ZJ[1];Chen, H[1];Han, ZJ[2];Chen, H[2]

机构：[1]Lanzhou Univ, Hosp 2, Dept Tumor Ctr, Key Lab Digest Syst Tumors Gansu Prov, Lanzhou, Peoples R China;[2]Lanzhou Univ, Clin Med Sch, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Hosp 2, Dept Tumor Ctr, Key Lab Digest Syst Tumors Gansu Prov, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Hosp 2, Dept Tumor Ctr, Key Lab Digest Syst Tumors Gansu Prov, Lanzhou, Peoples R China;[2]corresponding author), Lanzhou Univ, Clin Med Sch, Lanzhou, Peoples R China.

年份：2024

卷号：14

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85189625266);WOS:【SCI-EXPANDED(收录号:WOS:001198030800001)】；

基金：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Gansu Provincial Science and Technology Department Key R&D Program - Social Development Project (grant no. 23YFFA0067), Gansu Provincial Higher Education Innovation Fund Project (grant no. 2022A-071), Gansu Provincial Health and Industry Research Plan and Management Project (grant no. GSWSKY2020-60), Scientific Research and Innovation Fund Project of Gansu University of Chinese Medicine (grant no. 2019KC2D-1), General Project of the Affiliated Hospital of Gansu University of Chinese Medicine (grant no. gzfy-2022-07), Gansu Provincial Administration of Traditional Chinese Medicine, Open Project of Gansu Provincial Traditional Chinese Medicine Research Center (grant no. zyzx-2023-15), Project of the Gansu Provincial Science and Technology Department (Grant No. 18JR2FA002), the "National TCM Specialty Advantage Acupuncture Specialist" project funded by the Gansu Provincial Administration of Traditional Chinese Medicine, and National Natural Science Foundation of China (No. 82160129).

语种：英文

外文关键词：harmine; Peganum harmala; beta-carboline alkaloid; antitumor effect; mechanism of action; derivatives

摘要：Harmine is a naturally occurring beta-carboline alkaloid originally isolated from Peganum harmala. As a major active component, harmine exhibits a broad spectrum of pharmacological properties, particularly remarkable antitumor effects. Recent mechanistic studies have shown that harmine can inhibit cancer cell proliferation and metastasis through epithelial-to-mesenchymal transition, cell cycle regulation, angiogenesis, and the induction of tumor cell apoptosis. Furthermore, harmine reduces drug resistance when used in combination with chemotherapeutic drugs. Despite its remarkable antitumor activity, the application of harmine is limited by its poor solubility and toxic side effects, particularly neurotoxicity. Novel harmine derivatives have demonstrated strong clinical application prospects, but further validation based on drug activity, acute toxicity, and other aspects is necessary. Here, we present a review of recent research on the action mechanism of harmine in cancer treatment and the development of its derivatives, providing new insights into its potential clinical applications and strategies for mitigating its toxicity while enhancing its efficacy.