文献类型：期刊文献

英文题名：MicroRNA-126 Regulates Thrombosis Through Endothelial Progenitor Cells

作者：Xiao, Qian[1,2];Wang, Dan[1,2];Sheng, Yingda[1,2];Huang, Jing[1,2];Ha, Xiaoqin[2,3]

第一作者：Xiao, Qian

通信作者：Ha, X[1]

机构：[1]Gansu Univ Tradit Chinese Med, Sch Publ Hlth, Lanzhou, Peoples R China;[2]Ninth Forty Hosp Chinese Peoples Liberat Army Join, Dept Lab, Lanzhou, Peoples R China;[3]Ninth Forty Hosp Chinese Peoples Liberat Army Join, Dept Lab, 333 Nanbinhe Middle Rd, Lanzhou, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Ninth Forty Hosp Chinese Peoples Liberat Army Join, Dept Lab, 333 Nanbinhe Middle Rd, Lanzhou, Peoples R China.

年份：2023

卷号：42

期号：6

起止页码：315

外文期刊名：DNA AND CELL BIOLOGY

收录：;Scopus(收录号：2-s2.0-85160969815);WOS:【SCI-EXPANDED(收录号:WOS:000966522200001)】；

基金：This research was supported by the National Natural Science Foundation of China (Grant No. 81273568).

语种：英文

外文关键词：microRNA-126; endothelial progenitor cells; myeloid angiogenic cells; endothelial colony forming cells; thrombosis

摘要：Thrombosis is a common problem with potentially severe consequences. Endothelial progenitor cells (EPCs) show great potential as a thrombosis therapy due to their angiogenesis-promoting, thrombus-relieving, and anticoagulant functions. However, cell therapies present more clinical challenges than small molecule solutions. MicroRNAs (miRNAs) are small noncoding single-stranded RNAs with wide-ranging regulatory activities. miRNA-126 is highly enriched in EPCs and endothelial cells. Although increasing research showed that mircoRNA-126 (miR-126) can regulate EPC functions through various pathways and cytokines, summaries of these interactions are rare. Therefore, this brief review of recent findings on the relationship between miRNA-126 and EPC function will attempt to clarify the role of miR-126 in thrombosis through regulation of EPCs, with the goal of exploring alternative therapies for thrombotic diseases.