文献类型：期刊文献

中文题名：基于Citespace胃肠道菌群与骨代谢相关文献研究的可视化分析

英文题名：Visual analysis of literature on intestinal flora and bone metabolism by Citespace

作者：赵张凯[1];董万涛[1,2];王剑虹[1];常茹梦[1];张杰[1];杨攀[1]

第一作者：赵张凯

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730030;[2]甘肃中医药大学附属医院运动医学科,甘肃兰州730030

第一机构：甘肃中医药大学中医临床学院

年份：2023

卷号：44

期号：2

起止页码：315

中文期刊名：西安交通大学学报（医学版）

外文期刊名：Journal of Xi’an Jiaotong University（Medical Sciences）

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金资助项目(No.81960807);甘肃省科技厅重点研发计划-社会发展类项目(No.21YF5FA017);甘肃省创新基地和人才计划-自然科学基金(No.17JR5RA056);甘肃省高等学校创新基金项目(No.2021B-168)。

语种：中文

中文关键词：Citespace;肠道菌群;骨代谢;文献可视化分析;免疫

外文关键词：Citespace;gut microbiota;bone metabolism;visual analysis of literature;immunity

摘要：目的通过对胃肠道菌群与骨代谢相关研究文献分析,梳理当前研究热点及难点,为临床防治骨代谢相关疾病提供研究思路和方向。方法基于Citespace文献可视化分析软件,对纳入的394篇文献的关键词等信息进行共现和聚类分析,并绘制可视化图谱。结果纳入文献中,炎症性肠病、T细胞、树突状细胞、短链脂肪酸及慢性肾病等关键词出现频率高,肠碱性磷酸酶、代谢性骨关节炎、树突状细胞、信号通路等聚类簇是当前研究热点。该领域近年发文量增加迅速,美国发文量最多。结论肠道菌群干预免疫系统并调节骨代谢、维持骨稳态的机制仍是当前研究核心内容。
Objective To analyze the literature on the relationship between gut microbiota and bone metabolism,identify the current research hotspots and difficulties,and provide research ideas and directions for the clinical prevention and treatment of bone metabolism related diseases.Methods Based on the Citespace literature visualization analysis software,the co-occurrence and cluster analysis of keywords and other information of the included 394 literatures were performed,and the visual map was drawn.Results Among the included literatures,the keywords such as inflammatory bowel disease,T cells,dendritic cells,short-chain fatty acids,and chronic kidney disease appeared with high frequency.The cluster of intestinal alkaline phosphatase,metabolic osteoarthritis,dendritic cells,and signaling pathway was the current research hotspot.Recent years have witnessed a rapid increase in published articles in this field,with the United States as the leading origin.Conclusion The mechanism by which gut microbiota interferes with the immune system and regulates bone metabolism to maintain bone homeostasis is still the core of current research.