文献类型：期刊文献

英文题名：Inhibitors of the Wnt pathway in osteoporosis: Mechanisms of action and potential as therapeutic targets

作者：Song, Jiayi[1];Chang, Weirong[1];Wang, Yujie[2];Gao, Peng[1];Zhang, Jie[1];Xiao, Zhipan[2];An, Fangyu[3];Yan, Chunlu[2]

第一作者：Song, Jiayi

通信作者：Yan, CL[1];An, FY[2]

机构：[1]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Trad Chinese & Werstern Med, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Trad Chinese & Werstern Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

外文期刊名：BIOMOLECULES AND BIOMEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001362976900001)】；

基金：This review gets grants from the National Natural Science Foundation of China (82060872) , the Project of Gansu Chinese Medicine Bureau (GZKP-2023-39, GZKP-2023-63) , Research and Reform Project of Graduate Education and Teaching at Gansu University of Chinese Medicine (15) .

语种：英文

外文关键词：Wnt signaling pathway; osteoporosis; sclerostin; DKK1; WIF1; SFRP; bone metabolism

摘要：The Wnt signaling pathway is one of the most important and critical signaling pathways for maintaining cellular functions, such as cell proliferation and differentiation. Increasing evidence substantiates that the Wnt signaling pathway also plays a significant role in the regulation of bone formation in osteoporosis. Accordingly, inhibitors of this pathway, such as sclerostin, Dickkopf-1 (DKK1), WNT inhibitory factor 1 (WIF1), and secreted frizzled-related proteins (SFRPs), have a negative regulatory role in bone formation and may serve as effective therapeutic targets for osteoporosis. This review examines the mechanisms of action of Wnt signaling pathway inhibitors in osteoporosis, the relationship between the Wnt pathway and its inhibitors, and new molecular targets for osteoporosis treatment. Overall, the regulatory mechanisms of Wnt pathway inhibitors are summarized to provide scientific and theoretical guidance for the treatment and prevention of osteoporosis.