文献类型：期刊文献

中文题名：左归丸治疗绝经后骨质疏松症有效性的Meta分析

英文题名：A meta-analysis of the efficacy of Zuogui Wan on postmenopausal osteoporosis

作者：刘硕[1];赵希云[2];卢增鹏[1];李锦锋[1];张晓刚[2]

第一作者：刘硕

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2022

卷号：14

期号：23

起止页码：143

中文期刊名：中医临床研究

外文期刊名：Clinical Journal Of Chinese Medicine

基金：自重牵引复位器治疗腰椎病的开发及应用研究(18YF1FA043)。

语种：中文

中文关键词：左归丸;绝经后骨质疏松症;有效性;Meta分析

外文关键词：Zuogui Wan;Postmenopausal osteoporosis;Effectiveness;Meta-analysis

摘要：目的:系统评价左归丸治疗绝经后骨质疏松症的有效性。方法:计算机检索PubMed、The Cochrane Library、Embase、Web of Science、万方数据库、维普数据库、中国知网和中国生物医学文献数据库,收集左归丸治疗绝经后骨质疏松症的随机对照试验,检索时限均从建库至2021年10月1日。由2名研究者独立筛选文献,提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件合并研究数据。结果:共纳入15个随机对照试验,包括1287例患者。Meta分析结果显示:试验组的有效率、腰椎骨密度、股骨骨密度、雌二醇、碱性磷酸酶、中医证候积分均优于对照组。结论:现有证据表明,左归丸治疗绝经后骨质疏松症患者的疗效优于西医常规治疗。但受研究数量和质量限制,上述结论尚需开展更多高质量研究予以验证。
Objective:To systematically evaluate the efficacy of Zuogui Wan(左归丸)on postmenopausal osteoporosis.Methods:Randomized controlled trials(RCTs)of Zuogui Wan on postmenopausal osteoporosis were collected by computer retrieval from PubMed,The Cochrane Library,Embase,Web of Science,Wanfang,CNKI,VIP and CBM.The search timespan was set from inception to Oct 1,2021.After two researchers independently screened the literature,the data was extracted and the risk bias of included studies was evaluated.RevMan 5.3 software was used to conduct the meta-analysis.Results:A total of 15 RCTs were included,with 1287 patients.The meta-analysis results showed that compared with the control group,the effective rate,lumbar bone density,femoral bone density,estradiol,alkaline phosphatase,TCM syndrome score were all superior in the trial group.Conclusion:Current evidence shows that the efficacy of Zuogui Wan on postmenopausal osteoporosis is better than usual treatment.Limited by the quantity and quality of included studies,the above conclusion need to be verified by more large and high-quality trials.