文献类型：期刊文献

中文题名：3种椎动脉型颈椎病大鼠模型的建立与评价

英文题名：Establishment and evaluation of three kinds of cervical spondylosis of vertebral artery type rat model

作者：宋敏[1];李清林[1];孙定平[1];巩彦龙[1];刘涛[1];柴居堂[2];董万涛[2]

第一作者：宋敏

机构：[1]甘肃中医药大学;[2]甘肃中医药大学附属医院

第一机构：甘肃中医药大学

年份：2016

卷号：37

期号：3

起止页码：455

中文期刊名：西安交通大学学报：医学版

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；CSCD:【CSCD_E2015_2016】；

基金：国家自然科学基金项目(No.81360554);甘肃省重点中医药科研立项课题(No.GZK-2010-Z14);甘肃省中药现代制药工程研究院项目开发(No.2305083306);甘肃省高等学校研究生导师科研项目(No.1206-01)~~

语种：中文

中文关键词：混合造模法;椎动脉型颈椎病;造模评价

外文关键词：hybrid modeling method; cervical spondylosis of vertebral artery type;modeling evaluation

摘要：目的通过对3种椎动脉型颈椎病(CSA)模型大鼠学习记忆能力、焦虑抑郁度及神经精神紧张度的测定,对CSA大鼠造模方法进行比较和评价。方法将120只大鼠随机分为混合造模组、植骨压迫造模组、力学平衡失调造模组和空白对照组,每组30只,通过Morris水迷宫、高架十字迷宫实验及旷场实验对大鼠的学习记忆能力、焦虑抑郁度及神经精神紧张度进行检测和比较,对3种CSA大鼠模型进行评价。结果与空白对照组比较,混合造模组、植骨压迫造模组及力学平衡失调造模组的大鼠学习记忆能力明显下降,焦虑抑郁度及神经精神紧张度明显增高(P<0.05);与植骨压迫造模组及力学平衡失调造模组比较,混合造模组能更好的还原CSA发病特征。结论 3种造模方法均可以成功复制CSA动物模型,其中混合造模法更为优异,值得推广。
Objective To compare and evaluate the methods of building model of cervical spondylosis of vertebral artery type （CSA） rats by measuring the learning and memory ability, anxiety and depression, and degree of nervous tension of three kinds of CSA model rats. Methods We randomly divided 120 rats into mixed modeling group, bone graft compression modeling group, mechanical balance disorder modeling group, and blank control group with 30 rats in each. Morris water maze, elevated plus maze test and open field test were used to detect and compare the rats＇ abilities of learning and memory, anxiety and depression, and degree of nervous tension. We then evaluated the three CSA rat models. Results Compared with those in the blank group, the learning and memory abilities in the mixed modeling, bone graft compression and mechanical balance disorder modeling rats were significantly decreased, the anxiety and depression and degree of nervous tension were significantly increased （P~ 0.05）. Compared with bone graft compression and mechanical balance disorder modeling groups, the mixed modeling group could restore the characteristics of CSA. Conclusion The three kinds of modeling methods can successfully reproduce the CSA animal model; the mixed modeling is superior and thus worthy of promotion.