文献类型：期刊文献

英文题名：Pharmacokinetic Characterization of Ginsenoside Rd, an Ulcerative Colitis Targeted-Therapy Candidate, in Gastrointestinal Tract In Vivo by HPLC

作者：Liu, Xia[1,2];Yang, Weihu[3];Han, Wei[4];Yan, Shuai[1];Liu, Sha[1];Li, Hongxia[1];Chen, Jia[1];Zhang, Su[1];Chen, Xue[1];Gao, Mingtang[1];Wu, Yongjie[1]

第一作者：Liu, Xia

通信作者：Wu, YJ[1]

机构：[1]Lanzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China;[2]Lanzhou Univ, Sch Basic Med Sci, Med Res Ctr, Lanzhou 730000, Peoples R China;[3]Gansu Prov Matern & Child Care Hosp, Lanzhou, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.

年份：2014

卷号：33

期号：10

起止页码：1662

外文期刊名：LATIN AMERICAN JOURNAL OF PHARMACY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000347782500011)】；

基金：This study was supported by the Fundamental Research Funds for the Central universities (No. lzujbky-2012-149) and the Natural Science Foundation of Gansu Province of China (No. 1208 RJYA009).

语种：英文

外文关键词：Bioavailablity; Colon; Ginsenoside Rd; Intestine; Pharmacokinetic characterization

摘要：A previous study reported that ginsenoside Rd (GRd) after oral administration has a valuable effect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced recurrent ulcerative colitis. In this study, we use HPLC method to investigate the oral bioavailablity of GRd and found that GRd was very poorly absorbed following oral administration in vivo. Simultaneously, the amount of GRd was degraded 71.77 +/- 4.8% in the gastric juice, the amount of GRd in the colon 6 h after oral administration was 19.8 +/- 13.7% of the given dose. In further experiment, we found 81.25 +/- 9.74% of the given dose of GRd in the colon of mice after duodenal administration. GRd was detected and stable in the intestine contents of mice. These pharmacokinetic characteristics suggested that GRd affected the ulcerative colitis directly other than its a few other metabolic products. So that, it has a natural colon-targeting feature and it may be possibly developed as a therapeutic agent to inflammatory bowel disease.