文献类型：期刊文献

英文题名：Role of Peritoneal Mesothelial Cells in the Progression of Peritoneal Metastases

作者：Li, Junliang[1,2,3];Guo, Tiankang[1,2]

第一作者：李菊莲;Li, Junliang

通信作者：Guo, TK[1];Guo, TK[2]

机构：[1]Lanzhou Univ, Sch Clin Med 1, Lanzhou 730030, Peoples R China;[2]Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730030, Peoples R China;[3]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730030, Peoples R China

第一机构：Lanzhou Univ, Sch Clin Med 1, Lanzhou 730030, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Clin Med 1, Lanzhou 730030, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730030, Peoples R China.

年份：2022

卷号：14

期号：12

外文期刊名：CANCERS

收录：;Scopus(收录号：2-s2.0-85131598939);WOS:【SCI-EXPANDED(收录号:WOS:000817345700001)】；

基金：This study was supported by the Natural Science Foundation of Gansu Province (No. 20JR10RA372), Health Industry Research Project of Gansu Province (GSWSKY-2019-03), National Scientific Research Project Support Program of Gansu Provincial Hospital (19SYPYB-10), Open Fund Project of Gansu Key Laboratory of Molecular Diagnosis and Precision Therapy of Surgical Oncology (2020GSZDSYS02), Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences (NLDTG2020020), Scientific Research and Innovation Fund of Gansu University of Chinese Medicine (2020KCYB-7), Research project of Traditional Chinese Medicine of Gansu Province (GZKP2020-12) and Longyuan Youth Innovation and Entrepreneurship Talent Project (111266548053).

语种：英文

外文关键词：peritoneal mesothelial cells; peritoneal metastatic cancer; mesothelial-mesenchymal transition

摘要：Simple Summary Peritoneal mesothelial cells (PMCs) are the first cell layer to encounter peritoneal tumors, thereby affecting their progression. In the past, PMCs were considered a barrier to the intraperitoneal implantation and metastasis of tumors. However, the specific role of PMCs in local tumor progression remains controversial, with evidence demonstrating both inhibiting or promoting effects. The epithelial phenotype of PMCs exhibits an inhibitory effect on abdominal cavity metastasis, whereas the mesenchymal phenotype of PMCs significantly promotes the progression of abdominal cavity tumors. Nevertheless, the details of the interaction between PMCs and tumors to promote local progression and peritoneal dissemination require further study. This article presents a review of the role of PMCs in the progression of abdominal tumors. Based on existing evidence, maintaining the stability of the PMC epithelial phenotype may be a valuable target for inhibiting peritoneal tumor dissemination and local progression. Peritoneal metastatic cancer comprises a heterogeneous group of primary tumors that originate in the peritoneal cavity or metastasize into the peritoneal cavity from a different origin. Metastasis is a characteristic of end-stage disease, often indicative of a poor prognosis with limited treatment options. Peritoneal mesothelial cells (PMCs) are a thin layer of cells present on the surface of the peritoneum. They display differentiated characteristics in embryonic development and adults, representing the first cell layer encountering peritoneal tumors to affect their progression. PMCs have been traditionally considered a barrier to the intraperitoneal implantation and metastasis of tumors; however, recent studies indicate that PMCs can either inhibit or actively promote tumor progression through distinct mechanisms. This article presents a review of the role of PMCs in the progression of peritoneum implanted tumors, offering new ideas for therapeutic targets and related research.