文献类型：期刊文献

中文题名：四逆散对大鼠睡眠时相影响的实验研究

英文题名：Study on effects of Sini San on the sleeping phase in rats

作者：李越峰[1];徐富菊[1];张泽国[1];严兴科[1]

第一作者：李越峰

机构：[1]甘肃中医学院药学院

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2014

卷号：30

期号：10

起止页码：936

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：国家自然科学基金资助项目(81460611);教育部科学技术研究重点基金资助项目(212186);2014年度甘肃省自然科学基金资助项目(1010RJZA212;145RJZA076);甘肃省财政厅高校基本科研业务费专项基金资助项目(2013-2);2010甘肃中医学院引进人才科研启动基金资助项目(2010-3)

语种：中文

中文关键词：四逆散冻干粉;改善睡眠;睡眠时相;脑电图

外文关键词：freeze - dry powder of Sini San;sleeping phase;electroencephalogram

摘要：目的研究四逆散冻干粉对大鼠睡眠的影响。方法将埋好记录电极的大鼠随机分为2组(每组15只),分别为四逆散冻干粉组(给药组)和空白组,每天保证给药组明暗交替12 h,术后恢复2 d后,四逆散冻干粉4.95 g·kg-1连续灌胃给药7 d,空白组除灌胃给予蒸馏水外,其他处置方法同给药组。用脑电图分析并确定四逆散冻干粉对正常及失眠大鼠睡眠时相的影响。结果四逆散能延长正常与失眠大鼠的总睡眠时间,在睡眠时相上主要表现为延长慢波睡眠第2期(SWS2)和快速眼球运动睡眠(REMS),从而表明四逆散具有显著的改善睡眠作用。结论四逆散具有治疗失眠的作用。
Objective To study on the effects of freeze -dry powder of Sini San on sleep in rats.Methods Rats were randomly divided into two groups （freeze -dry powder of Sini San and blank groups ）of 15 each day to ensure the alternating light and dark 12 h.The postoperative recovery after two days, rats were continuously administered orally by freeze -dry powder of Sini San 4.95 g？ kg-1 for 7 days.Blank group was given dis-tilled water by intragastric way.The other disposal methods were the same with administration group.The efficacy of Sini San on sleeping phase of normal and insomnious rats are carried out by electroencephalo -gram （EEG）.Results The total sleeping time （TST） of rats were sig-nificantly prolonged induced by pentobarbital sodium , especially slow -wave sleep 2 （SWS2） and rapid -eye -movement sleep （REMS） were prolonged after the rats were orally administrated of Sini San freeze -dry powder for seven days.The result indicated that Sini San can significant effect on improving sleep.Conclusion There was the function of Sini San in the treatment for insomnia.