文献类型：期刊文献

英文题名：Role and mechanism of botanical drugs and their metabolites in osteoporosis: new strategies for clinical application

作者：Yang, Xiujuan[1,2,3];Li, Yuqi[1];Guo, Jingjing[1];Wang, Jiajia[1];Li, Shuo[1,2,3];Yang, Zhijun[1,2];Niu, Pengxian[1];Jiang, Yiwei[1];Song, Min[1];Hai, Yunxiang[1,3]

第一作者：Yang, Xiujuan;杨秀娟

通信作者：Jiang, YW[1];Song, M[1];Hai, YX[1];Hai, YX[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]Northwest Collaborat Innovat Ctr Tradit Chinese Me, Lanzhou, Peoples R China;[3]Ctr Tradit Chinese Med, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]corresponding author), Ctr Tradit Chinese Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：16

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105014523963);WOS:【SCI-EXPANDED(收录号:WOS:001556387800001)】；

基金：We thank Home for Researchers editorial team (www.home-for-researchers.com) for language editing service.

语种：英文

外文关键词：osteoporosis; bone; botanical drugs; metabolites; treatment

摘要：Osteoporosis, the most prevalent bone disease worldwide, is characterized by reduced bone mineral density and microarchitectural deterioration. Current pharmacological agents for osteoporosis management include bisphosphonates, calcitonin, estrogen, denosumab, and romosozumab. However, emerging evidence suggests these therapies may increase risks of breast cancer, ovarian cancer, osteonecrosis, and cardiovascular diseases. Consequently, safer therapeutic alternatives are required. Traditional botanical drugs, recognized for their favorable safety profiles compared to synthetic drugs, demonstrate increasing potential in osteoporosis treatment. This review examines classical pathogenic mechanisms of osteoporosis-including estrogen deficiency, oxidative stress, and dysregulated bone metabolism-and summarizes traditional botanical drugs: Astragalus polysaccharides (APS), glycyrrhizin, Cistanche deserticola polysaccharides (CDP), Eucommia ulmoides polysaccharides (EUP), and Ligustrum lucidum derivatives. These findings provide critical insights into osteoporosis pathomechanisms and identify promising therapeutic candidates for clinical translation.