文献类型：期刊文献

中文题名：颊针疗法在类风湿关节炎家兔模型镇痛效应中的特点研究

英文题名：Characteristics of the Analgesic Effect of Buccal Needle Therapy on Rheumatoid Arthritis with Rabbits as a Model

作者：蒲瑞生[1,2];方晓丽[1];颉旺军[1];刘丁龙[1];权可[1];苏成红[1];杨晨光[1];张延菊[1]

第一作者：蒲瑞生

机构：[1]甘肃中医药大学针灸推拿学院,甘肃省兰州市730000;[2]天水瑞生堂连锁国医馆,甘肃省天水市741000

第一机构：甘肃中医药大学针灸推拿学院

年份：2017

卷号：20

期号：33

起止页码：4183

中文期刊名：中国全科医学

外文期刊名：Chinese General Practice

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；

基金：国家自然科学基金资助项目(81260559)

语种：中文

中文关键词：关节炎,类风湿;针灸疗法;镇痛;剂量效应关系,针灸;颊针疗法

外文关键词：Arthritis,rheumatism; Acupuncture and moxibustion therapy; Analgesia; Dose - effect relationship,acupuncture and moxibustion; Buccal acupuncture

摘要：目的观察颊针疗法在类风湿关节炎兔模型镇痛效应中的特点,为颊针临床留针时间、疗程的制定提供理论依据。方法 2014年1—9月将筛选合格的40只清洁级大耳白兔随机分成正常组、模型组、体针组、颊针组,每组10只。模型组、体针组、颊针组制备类风湿关节炎兔模型,正常组不予处理。实验第27天开始正常组和模型组均予以体针组、颊针组相同方法固定30 min;体针组选双侧后肢膝眼和足三里针刺,留针30 min,1次/d;颊针组选颊针膝穴针刺,留针20 min,1次/d;4组均连续治疗10次,分别在治疗第1、4、7、10次针刺时测定针刺0、5、15、30、60、120、240 min各时间点痛阈值。结果第1、4、7、10次针刺方法和时间在痛阈值上存在交互作用(P<0.05),时间在痛阈值上主效应显著(P<0.05),针刺方法在痛阈值上主效应不显著(P>0.05)。正常组和模型组的痛阈值无时间效应(P>0.05),体针组和颊针组的痛阈值有时间效应(P<0.01)。颊针组时间在痛阈值上主效应显著(F=15.473,P<0.001),颊针组时间与针刺次数在痛阈值上不存在交互作用(F=0.973,P=0.486)。颊针组第1次针刺时镇痛效应量效曲线与第7次针刺时比较,差异有统计学意义(t=-3.227,P=0.012);颊针组第7次针刺时镇痛效应量效曲线与第10次针刺时比较,差异无统计学意义(t=0.463,P=0.656)。结论颊针疗法的镇痛效应具有明显的时间变化曲线,且具有起效快、上升快、下降亦快的特点。
Objective To evaluate the analgesic effect of buccal needle therapy in a rabbit model of rheumatoid arthritis, in order to provide a reference for the clinical needle-retaining duration and treatment course of buccal acupuncture. Methods This study was conducted from January to September,2014. Forty clean level white lop-eared rabbits were randomly divided into 4 groups,normal group,model group,body needle group and buccal needle group,with 10 in each. The model group,body needle group and buccal needle group were prepared as the rheumatoid arthritis model,while no treatment was applied for the normal group. Since the 27 th day after the starting of the experiment,both the model group and normal group were fixed for 30 min each day with the same method used for the body needle group and the buccal needle group; the rabbits of the body needle group were acupunctured at Xiyan points and Zusanli acupoints on bilateral hind limbs 1 time per day,the needle was retained for 30 min,and those in the buccal needle group were acupunctured at ＂ Xi＂ acupoints with buccal needle 1 time per day,the needle was retained for 20 min. All the four groups were treated 10 times continuously,and the pain thresholds were measured at acupuncture times of 0,5,15,30,60,120, and 240 min, respectively, during the 1 st,4 th,7 th and 10 th acupuncture treatments. Results Based on the pain thresholds, it was identified that there was interaction effect between acupuncture treatment method and duration（ P 0. 05） during the 1 st,4 th,7 th and 10 th acupuncture treatments. The principal effect produced by acupuncture treatment duration on pain threshold was significant（ P 0. 05）,while that produced by acupuncture treatment method on pain threshold was not（ P 0. 05）. The pain thresholds of the body needle group and buccal needle group were significantly affected by the acupuncture treatment duration（ P 0. 01）,but those of the normal group and the model group were not（ P 0. 05）. The principal effect of acupuncture treatment duration on pain threshold was significant in the buccal needle group（ F = 15. 473,P 0. 001）. There was no interaction effect between the duration of buccal needle treatment and the number of acupuncture on the pain threshold（ F = 0. 973,P = 0. 486）. The difference in the analgesic effect curves between the1 st and 7 th buccal needle acupuncture treatments was significant（ t =-3. 227, P = 0. 012）; but it was not significant（ t= 0. 463,P = 0. 656） between the 7 th and 10 th buccal needle acupuncture treatments. Conclusion The analgesic effect of buccal needle therapy has obvious time dependence, and it shows typical characteristics of quick response, rapid rise and decline.