文献类型：期刊文献

英文题名：Thyroid hormone levels in patients with bipolar disorder: a systematic review and meta-analysis

作者：Liu, Shanshan[1,2,5];Chen, Xiaoai[2,3,5];Li, Xiaotao[2,4,5];Tian, Limin[1,2,5]

第一作者：刘珊珊;Liu, Shanshan

通信作者：Tian, LM[1];Tian, LM[2];Tian, LM[3]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Endocrinol, Lanzhou, Gansu, Peoples R China;[3]Jiangsu Univ, Sch Med, Zhenjiang, Jiangsu, Peoples R China;[4]Lanzhou Univ, Sch Clin Med 1, Lanzhou, Gansu, Peoples R China;[5]Clin Res Ctr Metab Dis, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Endocrinol, Lanzhou, Gansu, Peoples R China;[3]corresponding author), Clin Res Ctr Metab Dis, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：24

期号：1

外文期刊名：BMC ENDOCRINE DISORDERS

收录：;Scopus(收录号：2-s2.0-85209361504);WOS:【SCI-EXPANDED(收录号:WOS:001356474800001)】；

基金：We are grateful for the contributions of the researchers and study participants, and the grant from the National Natural Science Foundation of China (No.82060152).

语种：英文

外文关键词：Bipolar disorder; Depression; Mania; Thyroid hormone; Meta-analysis

摘要：PurposeTo investigate the difference in blood (serum/plasma) thyroid hormone (TH) levels, including thyroid-stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3), free thyroxine (FT4), and free triiodothyronine (FT3), in bipolar disorder (BD) during different mood episodes (depression and mania) compared with healthy control (HC) and between manic episodes (BD-M) and depressive episodes (BD-D).MethodsAs of September 1, 2024, the electronic databases PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, China Science and Technology Journal Database, Wanfang Database, and Clinical Trials. Gov were systematically searched with no language limitations. Standardized mean differences (SMD) with 95% confidence interval (CI) were summarized using a random effects model. The chi-squared-based Q test and the I2 test assessed the size of heterogeneity.ResultsThe 21 studies included a total of 3696 participants, Of the 2942 BD patients, 1583 were in depressive episodes 1359 were in manic episodes. The status of measuring blood TH levels included 2 studies in plasma and 19 in serum. Combined with the results of the sensitivity analyses, we obtained the following relatively reliable results: serum T3 (SMD: -0.63, 95%CI: -1.09 to -0.17) and FT3 (SMD: -0.42, 95%CI: -0.83 to -0.00) levels decreased significantly in BD-D compared to HC; serum T3 (SMD: -0.91, 95%CI: -1.49 to -0.32) levels decreased significantly and serum FT4 (SMD: 0.37, 95%CI: 0.14 to 0.60) levels increased significantly in BD-M than in HC; serum T3 (SMD: 0.87, 95%CI: 0.24 to 1.49) and FT3 (SMD: 0.27, 95%CI: 0.13 to 0.42) levels demonstrated a significant elevation in BD-M compared to BD-D. In the group of euthyroidism, apart from serum FT4 (SMD: 0.21, 95%CI: -0.15 to 0.58) levels showed no significant difference between BD-M and HC, other results above remained consistent.ConclusionSerum T3 and FT3 levels decreased significantly in BD-D compared to HC. Serum T3 levels decreased significantly and serum FT4 levels increased significantly in BD-M compared to HC. Serum T3 and FT3 levels increased significantly in BD-M than in BD-D. The temporality of changes in TH levels and BD progression demands further longitudinal studies to illustrate.Trial registrationNumber and date of registration for prospectively registered trials No. CRD42022378530.