文献类型：期刊文献

英文题名：Mitochondria: a key regulator of programmed cell death in OP

作者：Wang, Kexin[1];Wang, Zhandong[2];Ma, Chunhua[1];Yang, Junfang[1];Xing, Shangman[1];Song, Bing[3];Guo, Chao[3];Song, Wenjing[1];Cao, Tingting[1];Bai, Min[4];Wang, Yongfeng[5]

第一作者：Wang, Kexin

通信作者：Bai, M[1];Wang, YF[2]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Clin Coll Integrated Tradit Chinese & Western Med, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Med Res & Expt Ctr, Lanzhou, Peoples R China;[4]Ningxia Med Univ, Coll Tradit Chinese Med, Yinchuan, Peoples R China;[5]Gansu Med Coll, Sch Basic Med, Pingliang, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Ningxia Med Univ, Coll Tradit Chinese Med, Yinchuan, Peoples R China;[2]corresponding author), Gansu Med Coll, Sch Basic Med, Pingliang, Peoples R China.

年份：2025

卷号：16

外文期刊名：FRONTIERS IN ENDOCRINOLOGY

收录：;Scopus(收录号：2-s2.0-105010841532);WOS:【SCI-EXPANDED(收录号:WOS:001528938700001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. University Industry Support Program Project funded by the Gansu Education Department, Project No.:2025CYZC-052;University Teacher Innovation Fund Project funded by the Gansu Education Department, Project No.:2025A-108;Pingliang City Key Research and Development Program supported by Pingliang Municipal Science and Technology Bureau, Project No.:PL-STK-2024A-031;Project supported by open Foundation of Key Laboratory of Dunhuang Medicine and Transformation,No.:DHYX24-18;Gansu Provincial Science and Technology Project supported by Science and Technology Program of Gansu Province, Project No.: 23YFFA0068.

语种：英文

外文关键词：osteoporosis; mitochondria; programmed cell death; apoptosis; necroptosis; pyroptosis; ferroptosis; mitophagy

摘要：Osteoporosis (OP) is a common clinical systemic bone disease, with insidious onset and usually causes serious complications such as fractures. Studies have found that the dysfunction of a variety of bone cells will lead to enhanced bone resorption and reduced bone formation capacity, thus resulting in the imbalance of bone homeostasis and OP disease. As a class of regulatory death mode that affects cell function, programmed cell death (PCD) has been proved to play an important role in maintaining various bone cells growth activities and maintaining bone homeostasis. In addition, several studies have shown that mitochondria are important regulators of a variety of PCD, and various drugs can target mitochondria to regulate the programmed death of bone cells, which is of great significance to further explore the pathogenesis of OP and look for new and efficient drugs for OP.