文献类型：期刊文献

中文题名：铁-脂紊乱在非酒精性脂肪性肝病中的作用及中药干预研究进展

英文题名：Role of Iron-lipid Disorder in Nonalcoholic Fatty Liver Disease and Research Progress of Traditional Chinese Medicine Intervention:A Review

作者：陈彦旭[1];张磊[1];金智生[1];张钦媛[1];姜晓雪[1];徐长青[1];豆鹏程[1];孙聪[2]

第一作者：陈彦旭

机构：[1]甘肃中医药大学,兰州730000;[2]山东中医药大学第二附属医院,济南250000

第一机构：甘肃中医药大学

年份：2024

卷号：30

期号：18

起止页码：281

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(82360914);甘肃省高等学校青年博士基金项目(2022QB-096)。

语种：中文

中文关键词：非酒精性脂肪性肝病(NAFLD);铁-脂紊乱;信号途径;中药;机制

外文关键词：nonalcoholic fatty liver disease(NAFLD);iron-lipid disorder;signal pathway;traditional Chinese medicine;mechanism

摘要：非酒精性脂肪性肝病(NAFLD)是2型糖尿病(T2DM)最常见的并发症之一。铁-脂紊乱引起的细胞死亡是一种调控细胞程序性死亡的新模式,特征包括脂质活性氧累积诱导的脂质过氧化与细胞铁离子代谢紊乱诱导的铁离子过度聚积。其中,铁离子稳态紊乱和代谢途径失调是铁-脂紊乱的主要原因,在细胞死亡相关的多种病理过程中起重要作用。由于肝脏是铁存储和脂质代谢的重要器官,因此铁-脂紊乱是肝病的理想靶点,而抑制铁-脂紊乱可能成为治疗NAFLD的新策略。但是,NAFLD与铁-脂紊乱的致病联系和机制尚未完全阐明。该文以铁-脂紊乱复杂的分子调控机制为切入点,通过阐述铁-脂紊乱在NAFLD的作用及其相关机制,归纳总结近年来中药针对铁-脂紊乱靶标治疗NAFLD的研究现状,为今后NAFLD的治疗提供新视角,指明新方向。
Nonalcoholic fatty liver disease(NAFLD)is one of the most common complications of type 2 diabetes mellitus(T2DM).Cell death caused by iron-lipid disorder is a new mode of regulating programmed cell death,which is characterized by lipid peroxidation induced by the accumulation of lipid reactive oxygen species and excessive accumulation of iron ions induced by iron metabolism disorders.Among them,iron homeostasis disorder and metabolic pathway disorder are the main causes of iron-lipid disorder,which play an important role in a variety of pathological processes related to cell death.Because the liver is an important organ for iron storage and lipid metabolism,iron-lipid disorder is an ideal target for liver disease,and inhibition of iron-lipid disorder may become a new strategy for the treatment of NAFLD.However,the pathogenic relationship and mechanism between NAFLD and iron-lipid disorder have not been fully elucidated.Based on the complex molecular regulation mechanism of iron-lipid disorder,by expounding the role of iron-lipid disorder in NAFLD and its related mechanism,this paper summarizes the research status of traditional Chinese medicine on the target treatment of NAFLD in recent years,so as to provide a new perspective and point out a new direction for the treatment of NAFLD in the future.