文献类型：期刊文献

中文题名：“脑-肠-骨骼”轴对骨质疏松症发病机制的影响

英文题名：Effect of brain-gut-bone axis on the pathogenesis of osteoporosis

作者：李平顺[1];王钢[2];周孟茹[3]

第一作者：李平顺

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院风湿骨病科,甘肃兰州730000;[3]兰州大学基础医学院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2020

卷号：26

期号：7

起止页码：1068

中文期刊名：中国骨质疏松杂志

外文期刊名：Chinese Journal of Osteoporosis

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：国家自然科学基金项目(81860858)。

语种：中文

中文关键词：骨质疏松;脑-肠-骨骼轴;微生物;骨-肌肉单位

外文关键词：osteoporosis;brain-gut-bone axis;microorganisms;bone-muscle unit

摘要：骨质疏松症是一种慢性、难治性代谢性骨病,深刻探讨其发病机制中的每一环节从而确立有效干预策略攻克这一顽疾成为近年来研究的热点。随着分子生物学进一步发展以及对脑-肠轴的深刻探讨,揭示了脑-肠轴可以以骨骼为潜在作用靶点,影响骨质疏松症的发病与发展。笔者以脑-肠-骨骼轴为基础,从脑-肠通讯、脑-骨通讯及肠-骨通讯三方面探讨骨质疏松症发病机制,以期为骨质疏松症防治新目标新策略的确立和机制研究提供理论思考。
Osteoporosis is a kind of chronic and refractory metabolic bone disease.It has become a hot research topic in recent years to explore every link of its pathogenesis in order to establish effective intervention strategies to overcome this stubborn disease.With the further development of molecular biology and the in-depth discussion of the brain-gut axis,it is revealed that the brain-gut axis can be a potential target of bone to affect the incidence and development of osteoporosis.Based on the brain-gut bone axis,this paper discusses the pathogenesis of osteoporosis from three aspects,including brain-gut communication,brain-bone communication,and enter-bone communication,so as to provide theoretical thinking for the establishment of new targets and new strategies for the prevention and treatment of osteoporosis and the study of the mechanism.