文献类型：期刊文献

英文题名：Chrysin: Phytochemistry, Pharmacology, Pharmacokinetics, Nano-Delivery Strategy, and Derivative Innovation

作者：Gong, Hui[1];Song, Xiaoxuan[2];Yu, Jia[6];Zhao, Xinke[3,4,5];Jiang, Hugang[1,3,4];Zhi, Xiaodong[1,3,4,5];Huang, Qun[7];Xie, Xin[2];Li, Xiang[2];Li, Yingdong[1,3,4]

第一作者：Gong, Hui

通信作者：Li, YD[1];Li, X[2]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, 35 Dingxi East Rd, Lanzhou 730000, Peoples R China;[2]Chengdu Univ Tradit Chinese Med, Coll Med Technol, Sch Pharm, 1166 Liutai Ave, Chengdu 611137, Peoples R China;[3]Gansu Prov Key Lab Chinese Med Prevent & Treatment, Lanzhou 730000, Peoples R China;[4]Key Specialized Cardiovasc Lab Natl Adm Tradit Chi, Key Clin Specialty Natl Hlth Commiss Peoples Repub, Lanzhou 730000, Peoples R China;[5]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China;[6]Shaanxi Univ Chinese Med, Coconstruct Collaborat Innovat Ctr Chinese Med Res, State Key Lab Res & Dev Characterist Qin Med Resou, Xianyang 712046, Peoples R China;[7]Hosp Chengdu Univ Tradit Chinese Med, Chengdu 610032, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, 35 Dingxi East Rd, Lanzhou 730000, Peoples R China;[2]corresponding author), Chengdu Univ Tradit Chinese Med, Coll Med Technol, Sch Pharm, 1166 Liutai Ave, Chengdu 611137, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：53

期号：08

起止页码：2465

外文期刊名：AMERICAN JOURNAL OF CHINESE MEDICINE

收录：;Scopus(收录号：2-s2.0-105024146059);WOS:【SCI-EXPANDED(收录号:WOS:001633564500006)】；

基金：This work was supported by the National Natural Science Foundation of China (82374279, 22307009), the Fundamental Research Funds of Science & Technology Department of Sichuan Province (2025ZNSFSC0601), the Gansu Province Major Science and Technology Special Project (20ZD7FA002), the Gansu Province Education Science and Technology Innovation Project (2021jyjbgs-03), and the Xinglin Scholar Research Promotion Project of Chengdu University of TCM (QJRC2023015).

语种：英文

外文关键词：Chrysin; Pharmacology; Combination Therapy; Pharmacokinetics; Drug Delivery Platforms; Derivatives

摘要：Chrysin, a naturally occurring flavonoid and FDA-approved dietary supplement, is ubiquitously present in fruits, vegetables, and mushrooms. Emerging evidence highlights its broad-spectrum therapeutic potential against diverse pathologies, including inflammation, cancers, organ injuries, metabolic dysfunctions, and neuropathic pain. Nevertheless, critical gaps persist in understanding its physicochemical properties, pharmacokinetic profile, and precise molecular mechanisms, and there remains only limited systematic evaluation of advanced drug delivery systems and structural modification strategies. This review comprehensively synthesizes cutting-edge advances in understanding chrysin's natural sources, physicochemical characteristics, pharmacological activities, pharmacokinetic features, innovative drug delivery systems, and chemical modifications. Through a rigorous analysis of peer-reviewed literature, we reveal that chrysin exerts its therapeutic effects predominantly by modulating key signaling pathways such as JAK/STAT3, NF-kappa B, and FOXM1/beta-catenin. Despite a poor oral bioavailability, next-generation nano-platforms have demonstrated remarkable efficacy in enhancing bioavailability and targeted delivery, while structure-optimized derivatives further amplify their therapeutic index. By integrating current knowledge, this work not only provides a holistic overview of chrysin as a multifunctional bioactive compound but also identifies pressing challenges. Targeted research in these areas is imperative to unlock the full translational potential of chrysin for clinical applications.