文献类型：期刊文献

英文题名：First-spike latency in Hodgkin's three classes of neurons

作者：Wang, Hengtong[1];Chen, Yueling[1,2];Chen, Yong[1]

第一作者：Wang, Hengtong

通信作者：Chen, Y[1]

机构：[1]Lanzhou Univ, Inst Theoret Phys, Lanzhou 730000, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Phys, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Inst Theoret Phys, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Inst Theoret Phys, Lanzhou 730000, Peoples R China.

年份：2013

卷号：328

起止页码：19

外文期刊名：JOURNAL OF THEORETICAL BIOLOGY

收录：;Scopus(收录号：2-s2.0-84876316590);WOS:【SCI-EXPANDED(收录号:WOS:000318960200003)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant nos. 10975063 and 11275084), the Fundamental Research Funds for the Central Universities (Grant no. lzujbky-2012-17), and the Program for New Century Excellent Talents in University (Grant no. NCET-11-0206).

语种：英文

外文关键词：Morris-Lecar neuron model; Neuron classification; Neural coding scheme; Temporal coding

摘要：We study the first-spike latency (FSL) in Hodgkin's three classes of neurons with the Morris-Lecar neuron model. It is found that all the three classes of neurons can encode an external stimulus into FSLs. With DC inputs, the FSLs of all of the neurons decrease with input intensity. With input current decreased to the threshold, class 1 neurons show an arbitrary long FSL whereas class 2 and 3 neurons exhibit the short-limit FSLs. When the input current is sinusoidal, the amplitude, frequency and initial phase can be encoded by all the three classes of neurons. The FSLs of all of the neurons decrease with the input amplitude and frequency. When the input frequency is too high, all of the neurons respond with infinite FSLs. When the initial phase increases, the FSL decreases and then jumps to a maximal value and finally decreases linearly. With changes in the input parameters, the FSLs of the class 1 and 2 neurons exhibit similar properties. However, the FSL of the class 3 neurons became slightly longer and only produces responses for a narrow range of initial phase if input frequencies are low. Moreover, our results also show that the FSL and firing rate responses are mutually independent processes and that neurons can encode an external stimulus into different FSLs and firing rates simultaneously. This finding is consistent with the current theory of dual or multiple complementary coding mechanisms. (C) 2013 Elsevier Ltd. All rights reserved.