文献类型：期刊文献

中文题名：耐甲氧西林金黄色葡萄球菌临床分布及耐药性分析

英文题名：Clinical distribution and drug resistance of methicillin-resistant Staphylococcus aureus strains

作者：朱吉超[1];魏莲花[2];杨永清[2];邵海鑫[3];邹凤梅[2];刘刚[2];吴玲[2];李军春[2]

第一作者：朱吉超

机构：[1]宁夏医科大学临床医学院;[2]甘肃省人民医院检验中心;[3]甘肃中医药大学

第一机构：宁夏医科大学临床医学院

年份：2017

卷号：27

期号：7

起止页码：1462

中文期刊名：中华医院感染学杂志

外文期刊名：Chinese Journal of Nosocomiology

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD_E2017_2018】；

基金：宁夏研究生教育创新计划基金资助项目(NXYC201511);甘肃省卫生行业科研基金资助项目(GSWST2012-04)

语种：中文

中文关键词：金黄色葡萄球菌;耐甲氧西林金黄色葡萄球菌;抗菌药物;耐药性

外文关键词：Staphylococcus aureus ; Methicillin-resistant Staphylococcus aureus; Antibiotics; Drug resistance

摘要：目的了解医院耐甲氧西林金黄色葡萄球菌(MRSA)临床分布及耐药状况,为临床治疗金黄色葡萄球菌感染提供合理用药依据。方法采用纸片扩散法(K-B法)对在2013-2015年医院就诊的患者标本中分离出的金黄色葡萄球菌947株进行药敏试验,根据2016年美国临床和实验室标准化协会(CLSI)指南判定药敏结果,并对MRSA的感染情况进行监测和分析。结果共检测出MRSA 382株,检出率40.3%,每年MRSA的检出率分别为39.6%、41.2%、40.2%;947株金黄色葡萄球菌主要分离自伤口分泌物和痰液,分别占30.7%、28.9%;烧伤科及耳鼻喉科分别占18.7%、11.5%;MRSA检出率较高科室是ICU和烧伤科,其检出率分别为68.8%、62.7%;MRSA对青霉素G、头孢呋辛、头孢噻肟、头孢唑林、苯唑西林、头孢西丁的耐药率均为100%。结论金黄色葡萄球菌的耐药率呈上升趋势,且MRSA的检出率日趋严重,需要定期对金黄色葡萄球菌进行监测,合理使用抗菌药物,防止MRSA的流行播散。
OBJECTIVE To investigate the distribution and drug resistance of methicillin-resistant Staphylococcus aureus（MRSA） in hospital, so as to provide reasonable basis of antibiotics for clinical treatment of S. aureus in- fection. METHODS By using disc diffusion（K-B method）, the susceptibility testing in 947 samples from patients in clinic and in hospital which infected S. aureus from 2013 to 2015 was carried out. The results of susceptibility tes- ting were according to the CLSI standard in 2016 and the infection of MRSA was monitored and analyzed. RESULTS Totally 382 strains of MRSA were detected, with the detection rate of 40.3%, and the detection rates of MRSA were 39.6%, 41.2% and 40.2% from 2013 to 2015, respectively. The 947 strains of S. aureus were mainly isolated from wound secretions and sputums, accounting for 30.7% and 28.9%, respectively. Those iso- lates mainly distributed in burn department and otolaryngology department, accounting for 18. 7% and 11.5%, respectively. The ICU and burn department had higher detection rate of MRSA, and the detection rates were 68. 8% and 62.7%, respectively. The drug resistant rates of MRSA to penicillin G, cefuroxime, cefotaxime, cefazo- lin, oxacillin and cefoxitin were all 100.0%. CONCLUSION The trend of drug resistance of S. aureus and the de- tection rate of MRSA are increasingly serious, so we need a regular monitoring of S. aureus, and use antibiotics reasonably, so as to prevent the popular spread of MRSA.