文献类型：期刊文献

中文题名：平胃分散片工艺研究

英文题名：Preparation Process of Pingwei Dispersible Tablets

作者：高建德[1];金辉[1];朱书强[1];余琰[1];范凌云[1]

第一作者：高建德

机构：[1]甘肃中医学院

第一机构：甘肃中医药大学

年份：2013

卷号：20

期号：5

起止页码：60

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2013_2014】；

语种：中文

中文关键词：平胃散;剂型改进;平胃分散片

外文关键词：Pingwei powder： formulation improvement; Pingwei dispersible tablets

摘要：目的研究平胃分散片的制备工艺。方法通过试验初步确定填充剂、崩解剂,并在多项指标控制下,对平胃分散片的处方进行优化。结果以交联羧甲基纤维素钠-交联聚乙烯吡咯烷酮-微晶纤维素混合物(1∶1∶5)为崩解剂,在4 kg/cm2压力下制备分散片最佳,平均崩解时限为2.5 min。结论该分散片处方合理、工艺可行、分散均匀、溶出快。
Objective To study the preparation process of Pingwei dispersible tablets. Methods Fillers and disintegrating agents were preliminarily determined by experiment. Under the control of multiple indicators, the preparation process of Pingwei dispersible tablets was optimized. Results With eCMC-Na, PVPP and MCC （1 ： 1 ： 5） as a disintegrant, the average disintegration lime of the dispersible tablets prepared under the optimized pressure of 4 kg/cm2 was 2.5 rain. Conclusion The process is reasonable and feasible. Pingwei dispersible tablets were stable, dissolved fast and completely.