文献类型：期刊文献

英文题名：Mechanism of HIF-1α-mediated angiogenesis in rheumatoid arthritis and progress of natural medicine interventions

作者：Wei, Yingjun[1];Xie, Xingwen[2,3];Hou, Xuan[4];Li, Dingpeng[1];Hou, Junhu[5];Gao, Yaxiong[5]

第一作者：魏於金

通信作者：Xie, XW[1];Xie, XW[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]Gansu Prov Hosp Tradit Chinese Med, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp 1, Lanzhou, Peoples R China;[4]Gansu Med Coll, Pingliang, Peoples R China;[5]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp 1, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：17

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105046949239);WOS:【SCI-EXPANDED(收录号:WOS:001822226200001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by: (1) Industry Support Program for Higher Education Institutions of Gansu Provincial Education Department (Grant No. 2023CYZC-57); (2) School (College) Enterprises Unveiled Marshal Project (Grant No. HXLH-JBGS01); (3) Gansu Provincial Key Project of Chinese Medicine Research (Grant No. GZKZ-2024-9); (4) Gansu Provincial Key Project of Scientific Research on Traditional Chinese Medicine (Grant No. GZKZ-2020-6); (5) Gansu Provincial Science and Technology Major Special Project (Grant No. 22ZD6FA021-4); (6) Lanzhou Science and Technology Program (Grant No. 2024-2-26); (7) 2026 Postgraduate Innovation and Entrepreneurship Project of Gansu University of Chinese Medicine (Grant No. 2026CXCY-031).

语种：英文

外文关键词：angiogenesis; HIF-1 alpha; natural medicine; rheumatoid arthritis; signaling pathway

摘要：Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by hyperplasia of synovial pannus and progressive joint destruction. Pathological angiogenesis, driven by hypoxia-inducible factor-1 alpha (HIF-1 alpha), constitutes a core pathological mechanism and has become a critical therapeutic target for RA. This article systematically elucidates the molecular mechanisms by which HIF-1 alpha drives pathological angiogenesis through interactions with signaling pathways such as vascular endothelial growth factor (VEGF), angiogenin (ANG)-1/2, CXC chemokine ligand 12 (CXCL12)/CXC chemokine receptor 4 (CXCR4), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR). HIF-1 alpha-mediated angiogenesis forms a positive feedback network with pathological processes including synovial inflammatory response, glycolytic metabolic reprogramming, and oxidative stress-mitochondrial damage, collectively promoting synovial pannus formation. Additionally, this article summarizes the effects of traditional Chinese medicine formulations and plant-derived monomeric metabolites on HIF-1 alpha-mediated RA synovial angiogenesis, as well as the preclinical research advances of anti-angiogenic mechanisms. It also briefly explores the potential of novel botanical drugs delivery systems in enhancing the targeting of natural products to the HIF-1 alpha pathway and improving therapeutic efficacy, aiming to provide new perspectives and strategic options for HIF-1 alpha-targeted RA therapies.