文献类型：期刊文献

中文题名：化瘀抗幽方联合西药治疗幽门螺杆菌相关性溃疡临床研究

英文题名：Clinical Study on Huayu Kangyou Formula Combined with Western Medicine for Hp-related Peptic Ulcer Disease

作者：蒲勤[1];魏淑海[2];王晋阳[3];徐健[1];孙成钢[1];魏利宝[1];郭奉忠[1]

第一作者：蒲勤

机构：[1]天水市第四人民医院,甘肃天水741020;[2]甘肃中医药大学附属医院,甘肃兰州730020;[3]甘肃中医药大学,甘肃兰州730020

第一机构：天水市第四人民医院,甘肃天水741020

年份：2015

卷号：22

期号：9

起止页码：30

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2015_2016】；

语种：中文

中文关键词：化瘀抗幽方;标准三联疗法;消化性溃疡;幽门螺杆菌

外文关键词：Huayu Kangyou Formula standard triple therapy; peptic ulcer; Hp

摘要：目的观察化瘀抗幽方联合西药治疗幽门螺杆菌(Hp)相关性溃疡临床疗效,并探讨其作用机理。方法将152例患者随机分为治疗组和对照组各76例,对照组予标准三联疗法,治疗组在标准三联疗法基础上予自拟方化瘀抗幽汤治疗,疗程6周,观察2组患者治疗前后临床症状积分、胃镜,记录不良反应,评价临床疗效,随访溃疡复发情况。结果治疗组、对照组临床总有效率分别为94.74%(72/76)、84.21%(64/76),治疗优良率分别为78.95%(60/76)、55.26%(42/76),不良反应发生率分别为5.26%(4/76)、13.16%(10/76),随访1年复发率分别为13.63%(6/44)、41.67%(10/24),差异均有统计学意义(P<0.05)。结论化瘀抗幽方联合西药治疗Hp相关性溃疡能够提高临床疗效,减少不良反应,降低溃疡复发率。
Objective To observe the efficacy of Huayu Kangyou Formula combined with Western medicine for Hp-related peptic ulcer disease; To discuss the mechanism of action. Methods Totally 152 patients were randomly divided into treatment group and control group, 76 cases in each group. Control group was given standard triple therapy, while treatment group was given Huayu Kangyou Formula based on the standard triple therapy. The treatment lasted for 6 weeks. The clincal symptom scores and gastroscopy were observed to evaluate the therapeutic effect, adverse reactions were recorded, and relapse of ulcer was followed-up. Results The total effective rates of clinical symptoms in the treatment group and the control group were 94.74% （72/76） and 84.21% （64/76）, respectively; the excellent rates were 78.95% （60/76） and 55.26% （42/76）, respectively; the incidences of adverse reactions were 5.26% （4/76） and 13.16% （10/76）, respectively; the relapse rates after 1 year of follow-up visit were 13.63% （6/44） and 41.67% （10/24）, respectively, with statistical significant difference between the two groups （P〈0.05）. Conclusion Huayu Kangyou Formula combined with Western medicine can effectively improve the efficacy of Hp-relative peptic ulcer disease, reduce adverse reaction rate and relapse rate.