文献类型：期刊文献

中文题名：黄芩炮制的历史沿革及现代研究进展

英文题名：Historical Evolution and Modern Research Progress of Processing of Scutellariae Radix

作者：林欢欢[1];邵长鑫[1];彭婷[1];姚娟[1]

第一作者：林欢欢

机构：[1]甘肃中医药大学药学院,兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2024

卷号：30

期号：3

起止页码：279

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金青年基金项目(82104370);甘肃省中药炮制技术传承基地项目;甘肃省自然科学基金项目(21JR1RA270);2022年陇原青年创新创业人才(个人)项目。

语种：中文

中文关键词：黄芩;炮制规范;历史沿革;化学成分;药理作用;中药饮片;物质基础

外文关键词：Scutellariae Radix;processing specification;historical evolution;chemical composition;pharmacological effect;traditional Chinese medicine decoction pieces;material basis

摘要：通过查阅历代本草古籍和近现代文献资料,笔者对黄芩炮制的历史沿革、近年相关炮制规范、现代炮制工艺、炮制品化学成分变化和药理作用机制等方面进行了系统整理和考证,以期为黄芩炮制饮片的进一步发展提供依据。通过古籍考证可知,黄芩古法炮制有酒制、醋制、盐制、蜜制、猪胆汁制、麦冬汁制、米泔水制、陈壁土制、童便制等多种辅料制法,以酒制法最为多样且分类细致,其中沿用至今的有黄芩片、炒黄芩、酒黄芩、黄芩炭等炮制品;黄芩现代炮制工艺主要集中在的软化切片、酒炙法和炒炭法等炮制方面,研究方法较为统一;目前研究发现黄芩炮制后发生变化的化学成分有黄酮类、多糖类、挥发油类和微量元素等,炮制品的药理作用有止血、抗菌、抗炎、抗氧化、镇痛解热、治疗肺部疾病、治疗结肠炎等,但在黄芩炮制的研究中,缺乏炮制致化学成分结构变化的研究和多种炮制饮片药理作用的综合比较研究。基于此,建议开展炮制工艺至炮制机制的系统研究,进一步探索黄芩炮制前后物质基础的变化规律与药理作用间的关系,深化黄芩炮制品在分子机制和临床应用层面的探索,以期阐明黄芩炮制机制的科学内涵,为后续黄芩炮制饮片的扩大应用及其炮制标准的制定奠定基础。
By consulting ancient herbal books and modern literature,this paper systematically sorted out and researched the processing history,relevant processing norms in recent years,modern processing technology,chemical composition changes of processed products and their pharmacological mechanism of Scutellariae Radix,in order to provide a basis for the further development of Scutellariae Radix decoction pieces.According to the textual research of ancient books,there were many kinds of processing auxiliary materials of Scutellariae Radix,such as wine,vinegar,salt,honey,pig bile and so on,among which the wine processing was the most diverse and detailed,and the processed products such as raw products,stir-fried products,wine-processed products,fried charcoal products were still in use.The modern processing techniques of Scutellariae Radix mainly focus on the processing aspects of softening and slicing,wine processing and charcoal frying,and the research methods are relatively unified.At present,it is found that the changed chemical constituents of Scutellariae Radix after processing are flavonoids,polysaccharides,volatile oils and trace elements,etc.Pharmacological effects of processed products are hemostasis,antibacterial,anti-inflammatory,antioxidant,analgesic and antipyretic,treatment of lung diseases,treatment of colitis,etc.However,in the studies of Scutellariae Radix processing,there is a lack of research on the structural changes of chemical components caused by processing and a comprehensive comparative study on the pharmacological effects of various processed products.Based on this,it is suggested to carry out systematic research on the processing technology to processing mechanism,further explore the relationship between the change rule of material basis and pharmacological action before and after processing of Scutellariae Radix,and deepen the exploration of molecular mechanism and clinical application of processed products of Scutellariae Radix,in order to clarify the scientific connotation of the processing mechanism of Scutellariae Radix,and lay a foundation for the subsequent expansion of the application of Scutellariae Radix decoction pieces and the formulation of processing standards.