文献类型：期刊文献

英文题名：Angelica sinensis polysaccharide extends lifespan and ameliorates aging-related diseases via insulin and TOR signaling pathways, and antioxidant ability in Drosophila

作者：Tuo, Wenjuan[1,2]; Wang, Shuwei[3]; Shi, Yan[1,2]; Cao, Wangjie[1,2,4]; Liu, Yongqi[1,4]; Su, Yun[1,4]; Xiu, Minghui[3,4]; He, Jianzheng[1,2,4]

第一作者：Tuo, Wenjuan

机构：[1] Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [2] College of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [3] College of Public Health, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [4] Key Laboratory of Dunhuang Medicine, Ministry of Education, Lanzhou, 730000, China

第一机构：甘肃中医药大学

通信机构：[3]College of Public Health, Gansu University of Chinese Medicine, Lanzhou, 730000, China;[1]Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou, 730000, China|[10735]甘肃中医药大学;

年份：2023

卷号：241

外文期刊名：International Journal of Biological Macromolecules

收录：EI(收录号：20231914081010);Scopus(收录号：2-s2.0-85158852171)

语种：英文

外文关键词：Cell proliferation - Cell signaling - Insulin - Neurodegenerative diseases - Sleep research - Stem cells

摘要：Angelica sinensis polysaccharide (ASP) is one of the principal active components of Angelica sinensis (AS) that is widely used in natural medicine and has various pharmacological activities, including antioxidant, anti-inflammatory, and enhancing immunity. However, its pharmacological role of anti-aging needs to be clarified. Here, we detected the beneficial effect and mechanism of ASP on healthy aging and aging-related diseases using the Drosophila melanogaster model. The results showed that oral administration of ASP remarkably extended lifespan, increased reproduction, improved climbing ability, and increased resistance to starvation and oxidative stress in aged flies, mainly via inhibiting insulin signaling (IIS) and TOR signaling and boosting antioxidant ability. Further, ASP supplementation protected against aging-induced intestinal homeostasis imbalance via inhibiting intestinal stem cells (ISCs) hyperproliferation and oxidative damage, improved sleep disorders via rescuing sleep rhythm in aged flies, and had a neuroprotective effect on Aβ42 transgenic flies. Taken together, our findings shed light on the possibility that ASP could increase lifespan, improve healthy aging, and ultimately reduce the incidence of age-related illnesses. It holds promise as a candidate for anti-aging intervention and treatment for aging-associated disorders. ? 2023 Elsevier B.V.