文献类型：期刊文献

中文题名：线粒体动力学在糖尿病足溃疡中的作用机制及其相关干预策略研究进展

英文题名：Research progress on the mechanism of mitochondrial dynamics in diabetic foot ulcers and its related intervention strategies

作者：陕斌[1];郭泽澳[2];马学鹏[2];井帅帅[2];吴瑜[2];潘海邦[2];曾昭洋[2]

第一作者：陕斌

机构：[1]甘肃中医药大学附属医院关节外科,兰州730000;[2]甘肃中医药大学中西医结合学院,兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2026

卷号：42

期号：5

起止页码：496

中文期刊名：中华烧伤与创面修复杂志

外文期刊名：Chinese Journal of Burns And Wounds

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金地区科学基金项目(82560950);甘肃省联合基金一般项目(24JRRA881);兰州市科技计划项目(2023-ZD-210);兰州市城关区科技计划项目(2022SHFZ0021)。

语种：中文

中文关键词：糖尿病足;溃疡;线粒体动力学;线粒体分裂与融合;创面修复

外文关键词：Diabetic foot;Ulcer;Mitochondrial dynamics;Mitochondrial fission and fusion;Wound repair

摘要：糖尿病足溃疡(DFU)是糖尿病患者常见且严重的慢性并发症,具有高复发率、致残和致死风险,给个人健康与社会医疗系统带来沉重负担。线粒体动力学指线粒体通过分裂与融合的动态平衡维持细胞的能量代谢和稳态,而在糖尿病病理环境中,高血糖和氧化应激会破坏这一平衡,导致线粒体功能紊乱,进一步加剧DFU的炎症反应和组织损伤。近年来,靶向线粒体动力学的干预策略被认为是改善DFU症状、促进创面愈合的潜在治疗手段。该文基于国内外最新研究,综述DFU中线粒体动力学的研究进展,重点探讨其在DFU病理过程中的核心作用机制及调控因素,并总结当前主要的干预策略。通过系统分析,该文旨在加深对DFU相关线粒体动力学机制的理解,为临床提供新的靶向治疗思路。
Diabetic foot ulcer(DFU)is a common and serious chronic complication in patients with diabetes,characterized by high recurrence rates,risks of disability and mortality,which imposes a heavy burden on individual health and the social healthcare system.Mitochondrial dynamics refer to the dynamic balance between mitochondrial fission and fusion that maintains cellular energy metabolism and homeostasis.However,in the pathological environment of diabetes,hyperglycemia and oxidative stress disrupt this balance,leading to mitochondrial dysfunction and further exacerbating the inflammatory response and tissue damage in DFU.In recent years,intervention strategies targeting mitochondrial dynamics have been considered a potential therapeutic approach to alleviate DFU symptoms and promote wound healing.Based on the latest domestic and international research,this article reviews the progress of research on mitochondrial dynamics in DFU,with a focus on exploring its core mechanisms and regulatory factors in the pathological process of DFU,and summarizes the current main intervention strategies.Through systematic analysis,this article aims to deepen the understanding of the mechanisms underlying mitochondrial dynamics in DFU and to provide new ideas for targeted therapy in clinical practice.